Vnutriplevral'naya immunoterapiya interleykinom-2 bol'nykh s metastaticheskim plevritom
K S Titov , L V Demidov , M V Kiselevskiy , I Zh Shubina , I N Mikhaylova , L M Rodionova , K Yu Topol' , I E Sinel'nikov , A N Gritsay
Russian Journal of Oncology ›› 2010, Vol. 15 ›› Issue (4) : 20 -24.
Vnutriplevral'naya immunoterapiya interleykinom-2 bol'nykh s metastaticheskim plevritom
The paper gives the results of a study of the clinical efficiency of intrapleural immunotherapy with low-dose recombinant interleukin-2 (roncoleukin®) in patients with metastatic exudative pleurisy in breast cancer, non-small cell lung cancer, ovarian cancer, etc. It has been shown that this treatment modality is highly effective (an objective response was 84%), increases longevity and quality of life in patients, rarely causes recurrences, and it is easy-to-use and well tolerated. Intrapleural immunotherapy for malignant pleural effusion may be successfully used in drug-unresponsive patients and it is one of the stages of multimodality therapy for a disseminated tumor process.
metastatic pleurisy / intrapleural immunotherapy / interleukin-2
| [1] |
Давыдов М. И., Оразгельдыев К. Р., Волков С. М., Киселевский М. В. // Новое в онкологии: Сборник науч. трудов. - М., 2001. - Вып. 5. - С. 72-88. |
| [2] |
Кашикова Х. Ш. Лекарственная терапия опухолевых плевритов: Дис. .. канд. мед. наук. - М., 1989. |
| [3] |
Киселевский М. В. // Вестн. РАМН. - 2003. - № 1. - С. 40-44. |
| [4] |
Чикилева И. О., Халтурина Е. О., Киселевский М. В. // Молекул. мед. - 2003. - № 2. - С. 40-50. |
| [5] |
Aarts F., Bleichrodt R. P., Oyen W. J., Boerman O. C. // Cancer Biother. Radiopharm. - 2008. - Vol. 23. - P. 92-107. |
| [6] |
Balassoulis G., Sichletidis L., Spyratos D. et al. // Am. J. Clin. Oncol. - 2008. - Vol. 3. - P. 384-389. |
| [7] |
Bayly T. C., Kisher D. L., Sybert A. et al. // Cancer. - 1978. - Vol. 41. - P. 188-192. |
| [8] |
Blymenberg A. G., Kiselevski M. V., Gorbunova V. A. et al. // Int. J. Gynecol. Cancer. - 2002. - Vol. 12, N 5. - P. 70. |
| [9] |
Chen H., Brahmer J. // Curr. Oncol. Rep. - 2008. - Vol. 10. - P. 287-293. |
| [10] |
Colt H. G., Davoudi M. // Lancet Oncol. - 2008. - Vol. 9. - P. 12-13. |
| [11] |
Hausher F. H., Yarbo J. W. // Cancer Met. Rev. - 1987. - Vol. 6. - P. 24-30. |
| [12] |
Kefford R. F., Woods R. L., Fox R. et al. // Med. J. Austr. - 1980. - Vol. 12. - P. 447-449. |
| [13] |
Leff A., Hopewell P., Costello J. // Ann. Intern. Med. - 1978. - Vol. 88. - P. 532-537. |
| [14] |
Liu X., Li D., Zhang C., Ba D. et al. // Med. Sci. J. - 1993. - Vol. 8. - P. 186-189. |
| [15] |
Ohara M., Okada M. // Hiroshima J. Med. Sci. - 2008. - Vol. 57. - P. 37-46. |
| [16] |
Rosenberg S. A., Lotze B., Muul L. et al. // N. Engl. J. Med. - 1985. - Vol. 314. - P. 1485-1492. |
| [17] |
Rosenberg S. A., Lotze B., Yang J. C. et al. // J. Natl. Cancer Int. - 1993. - Vol. 85. - P. 632-662. |
| [18] |
Wallach H. W. // Chest. - 1975. - Vol. 68. - P. 510-512. |
Eco-Vector
/
| 〈 |
|
〉 |
PDF
