Neoad\"yuvantnaya prolongirovannaya khimioluchevaya terapiya s posleduyushchey gastrektomiey D2 u bol'nykh mestno-rasprostranennym rakom zheludka
V Yu Skoropad , B A Berdov , L N Titova , Yu S Mardynskiy , L V Evdokimov , N K Silant'eva , T A Agababyan , Yu T Neborak , V V Agafonov
Russian Journal of Oncology ›› 2010, Vol. 15 ›› Issue (4) : 10 -15.
Neoad\"yuvantnaya prolongirovannaya khimioluchevaya terapiya s posleduyushchey gastrektomiey D2 u bol'nykh mestno-rasprostranennym rakom zheludka
The authors report the preliminary results of Phase II clinical trial of the new method of multimodal treatment for locally advanced gastric cancer - preoperative neoadjuvant chemoradiotherapy. The procedure for the latter is well tolerated by patients and causes moderate, treatable reactions. Preoperative exposure does not complicate surgical intervention. There were no postoperative complications or deaths. The clinical and morphological evaluation of tumor responses showed that most patients had significant regression of both a primary tumor and regional metastases. Long-term neoadjuvant chemoradiotherapy followed by D2 gastrectomy in patients with locally advanced gastric cancer is a warranted and promising treatment calling for further clinical studies.
locally advanced gastric cancer / neoadjuvant chemoradiotherapy / D2 gastrectomy / combination treatment
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