Synchronous polyneoplasias in patients with gastric cancer: clinical and morphological regularities, treatment results

Abstract

The paper analyzes synchronous polyneoplasias in radically operated patients with gastric cancer, which were detected in 2.9% of cases, including 7.3% among the patients with early gastric cancer. Among second tumors, there was a preponderance of neoplasms of the colon, urinary bladder, throat, lung, and kidney. Preoperative examination of patients with gastric cancer should exclude synchronous tumors of the most common sites. Conversely, gastroscopy should be included in a diagnostic algorithm for patients with the above neoplasms to exclude gastric cancer. Synchronous multiplicity of the disease is shown to be a contraindication to the radical treatment of each neoplasm. If reasonably effective palliative therapy for a second tumor can be performed during its generalizations, radical surgical treatment for gastric cancer is warranted. If there are technical feasibilities and the patient's functional status is adequate, simultaneous removal of both tumors is the method of choice. Radical treatment for synchronous tumors ensures high survival rates. In this patient category, the cardinal cause of death is second tumor progression, which is associated with the predominance of early gastric cancer.

Keywords

synchronous polyneoplasias / gastric cancer / surgical treatment / combination treatment / long-term results

References

[1] Злокачественные новообразования в России в 2007 г. (заболеваемость и смертность) / Под ред. В. И. Чиссова и др. - М., 2009.

[2] Чиссов В. И., Вашакмадзе Л. А., Бутенко А. В., Морозов П. А. // Первично-множественные злокачественные опухоли / Под ред. В. И. Чиссова, А. Х. Трахтенберга. - М., 2000. - С. 233-241.

[3] Юрин А. Г. // Вопр. онкол. - 2003. - № 3. - С. 376-383.

[4] AJCC Cancer Staging Handbook. TNM Classification of Malignant Tumors. - 6-th Ed. - 2002.

[5] Cheng H. Y., Chu C. H., Chang W. H. et al. // Wld J. Gastroenterol. - 2005. - Vol. 11. - P. 4215-4219.

[6] Ha T. K., An J. Y., Youn H. G. et al. // Yonsei Med. J. - 2007. - Vol. 48. - P. 981-987.

[7] Ikeda Y., Saku M., Kawanaka H. et al. // Oncology. - 2003. - Vol. 65. - P. 113-117.

[8] Lee J. H., Bae J. S., Ryu K. W. et al. // Wld J. Gastroenterol. - 2006. - Vol. 12. - P. 2588-2592.

[9] Molinero A. M., Plaza F. J., Arino T. R. et al. // Rev. Esp. Enferm. Dig. - 2006. - Vol. 98. - P. 907-916.

[10] Warren S., Gates O. // Am. J. Cancer. - 1932. - Vol. 16. - P. 1358-1414.

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