METODOLOGIChESKIE ASPEKTY INTRAOPERATsIONNOY FOTODINAMIChESKOY TERAPII PRI MESTNO-RASPROSTRANENNOM RAKE MOLOChNOY ZhELEZY
E V Filonenko , D D Pak , E K Saribekyan , G S Barsamyan , G A Frank , Yu Yu Andreeva , G P Krylova , M V Ermoshchenkova
Russian Journal of Oncology ›› 2010, Vol. 15 ›› Issue (6) : 28 -32.
METODOLOGIChESKIE ASPEKTY INTRAOPERATsIONNOY FOTODINAMIChESKOY TERAPII PRI MESTNO-RASPROSTRANENNOM RAKE MOLOChNOY ZhELEZY
The authors give their experience with intraoperative photodynamic therapy used in 79 patients with Stages IIB, IIIA, B, and C breast cancer. When its procedure was being developed, the tissue distribution of alasens-induced protoporphyrin IX (PPIX) and photosens was studied in the normal tissue and tumor of the breast. The study showed the specific features of PPIX accumulation in the tumor in relation to the performance of neoadjuvant chemotherapy. Analysis of 3-year treatment results revealed no disease progression in 17 (50%) patients; 5 (14.7%) patients were diagnosed as having a locoregional recurrence; distant metastases were detected in 12 (35.5%). Intraoperative photodynamic therapy has prospects for treating locally advanced breast cancer in order to enhance intraoperative ablastics, devitalization of cancer cells of the wound surface and to prevent a local recurrence.
breast cancer / fluorescence diagnosis / intraoperative photodynamic therapy
| [1] |
Пак Д. Д., Сарибекян Э. К., Пономарев Р. С. // Материалы III съезда онкологов и радиологов СНГ. - Минск, 2004. - Ч. 2. - С. 66-67. |
| [2] |
Пак Д. Д., Сарибекян Э. К. // Руководство по онкологии / Под ред. В. И. Чиссова, С. Л. Дарьяловой. - М., 2008. - С. 382-408. |
| [3] |
Сарибекян Э. К., Пак Д. Д. // Проблемы диагностики и лечения рака молочной железы: Материалы 1-й Международной ежегодной онкологической конференции. - СПб., 2004. - С. 135. |
| [4] |
Соколов В. В., Филоненко Е. В., Чиссов В. И., Карпова Е. С. // Хирург. - 2008. - № 6. - С. 40-45. |
| [5] |
Филинов В. Л., Сдвижков А. М., Борисов В. И., Соколов В. В. // Паллиатив. мед. и реабил. - 2004. - № 3. |
| [6] |
Филоненко Е. В. Флюоресцентная диагностика и фотодинамическая терапия в онкологии: Дис. ... д-ра мед. наук. - М., 2006. |
| [7] |
Чиссов В. И., Старинский В. В., Петрова Г. В. Злокачественные новообразования в России в 2007 г. (Заболеваемость и смертность). - М., 2009. |
| [8] |
Bellnier D. A., Henderson B. W., Pandey R. K. et al. // J. Photochem. Photobiol. - 1993. - Vol. 20. - P. 55-61. |
| [9] |
Bonett R. // Chem. Soc. Rev. - 1995. - Vol. 24. - P. 19-33. |
| [10] |
Dolmans D. E., Fukumura D., Jain R. K. // Nat. Rev. Cancer. - 2003. - Vol. 3, N 5. - P. 380-387. |
| [11] |
Dougherty T. J., Gomer C. J., Henderson B. W. et al. // J. Natl. Cancer. Inst. - 1998. - Vol. 90, N 12. - P. 889-905. |
| [12] |
Henderson B. W., Dougherty T. J. // Photochem. Photobiol. - 1992. - Vol. 55. - P. 145-157. |
| [13] |
Warloel T., Herdahll H., Peng Q. et al. // Photodynamic Therapy (PDT) of Malignant Mesothelioma of Pleura. - Oslo. |
Eco-Vector
/
| 〈 |
|
〉 |
PDF
