Protivoopukholevye vaktsiny na osnove dendritom
K D Nikitin , M A Rubtsova , I A Utyashev , A Yu Baryshnikov
Russian Journal of Oncology ›› 2010, Vol. 15 ›› Issue (2) : 48 -53.
Protivoopukholevye vaktsiny na osnove dendritom
Immunotherapy is an oncology area that studies how to treat malignancies, by activating and/or potentiating an antitumor immune response in the patient. Much attention is given to the use of dendritic cells and their based agents (vaccines). Pilot clinical trials have demonstrated that dendritic cells loaded with tumor antigens induce an immune response that is specific to tumor-associated antigens. Dendritic/tumor cell fusion is one of the most original and very promising methods for enhancing the efficacy of dendritic cell vaccines. The present overview presents information on the dendritoma obtaining procedure, discusses the specific features of the biology of hybrid cells, and the results of their experimental study. Particular emphasis is laid on the data of clinical studies of dendritomas in patients with malignancies.
antitumor vaccines / dendritomes
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