Tartratrezistentnaya kislaya fosfataza osteoklastov (TRAP-5b) v syvorotke krovi u patsientov s pervichnymi opukholyami kostey

Abstract

The purpose of the ivestigation was to study whether osteoclast-derived serum tartrate-resistant acid (TRAP-5b) can be used as a tumor marker in the presence of primary bone neoplasms. The study included 34 patients with primary bone malignancies (Group 1), 35 with benign tumors and traumatic bone fractures (Group 2), and 38 apparently healthy donors (Group 3). All the groups were age-matched and gender-matched. TRAP-5b levels were studied by enzyme immunoassay. The low (less than 3 U/l) serum concentration of TRAP-5b was found in 39, 31, and 3% in Groups 1, 2, and 3, respectively. The TRAP-5b levels exceeding 6.0 U/l were seen in 1 examinee from Group 3, in 1 patient from Group 2 and in 35% of Group 1 patients. The highest concentrations (7.74±0.73 U/l) of TRAP-5b were detected in patients with osteolytic bone destruction, the least (4.48±0.92 U/l) in mixed one.

Keywords

serological markers / primary bone malignancies / the bone resorption marker TRAP-5b

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