Comt val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor (Science. — 2003. —Feb. 21. — 299(5610). — P. 1240—1243: англ.)
J. Zubieta , M. Heitzeg , Y. Smith , J. Bueller , K. Xu , Y. Xu , R. Коерре , C. Stohler , D. Goldman
Neurology Bulletin ›› 2003, Vol. XXXV ›› Issue (1-2) : 78 -78.
Comt val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor (Science. — 2003. —Feb. 21. — 299(5610). — P. 1240—1243: англ.)
The catechol-O-methyl-transferase (COMT) gene regulates the metabolic processes of the neurotransmitter dopamine and, through it, influences endorphins, which play an important role in the process of pain perception. It was found that the COMT gene with the amino acid valine (val158) is more active than the variant of the gene containing methionine (met158).
Zubieta J., Heitzeg M., Smith Y., Bueller J., Xu K., Xu Y., Коерре R., Stohler C., Goldman D.
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