Clinical and immunological indications of diffuse connective tissue diseases in patients with multiple sclerosis

Abstract

Discovered at multiple sclerosis the disturbance of operation of an immune system in many respects are similar to defects at a number classical autoimmune diseases. In the patients with multiple sclerosis are revealed by us the clinical indications close to those at diffuse connective tissue diseases, in particular, at system scleroderma. It was investigated the levels of serum autoantibodies to native and denature DNA in multiple sclerosis and system scleroderma. It was discovered the association of the increased levels of autoantibodies to DNA and the first stage of multiple sclerosis. The data, obtained by us, testify to a generality pathogenesis of multiple sclerosis and autoimmune connective tissue diseases at early stages of their origin with a further divergence of paths of their development.

Keywords

Bekhterev neurology archive

References

[1] Барановский А.Г., Канышкова Т.Г., Могельницкий А.С. и др. // Биохимия. — 1998. — 63 (11) — С. 1459—1469.

[2] Матвеева Т.В., Арлеевская М.И., Демин Т.В // Неврол. вести. — 1998. — № 3—4. — С. 60—64.

[3] Насонова В.А., Бунчук Н.В. Ревматические болезни. — М., 1997.

[4] Саттарова Л.И., Гафиятуллина Л.А., Аглиуллина Д.Г., Винтер В.Г. //Биотехнология. —1994. —№ 11—12. — С. 38—41.

[5] Allinquant В., Schuller Е. // Pathol. Biol. (Paris) — 1987. — Vol. 35 (3). — P. 291—298.

[6] Kira J., Goto I. // J. Neurol. Neurosurg Psychiatry. — 1994. — Vol. 57 (9). — P. 1124—1125.

[7] Poser C.M., Party D.W., Scheinberg L. et al. // Ann. Neurol. — 1983. — Vol. 13 (2). — Vol. 227—231.

[8] Williamson R.A., Burgoon M.P., Owens G.P. et al. // Proc. Natl. Acad. Sci. USA. — 2001. Vol 98 (4). —P. 1793—1798.

RIGHTS & PERMISSIONS

Sultanova I.V., Kolikova Y.O., Ishmuhametova D.G., Matveeva T.V., Arleevskaya M.I.