Error-related negativity: neurocognitive transdiagnostic marker of anxiety disorders

Abstract

The article is devoted to the analysis of the prospects for research on neurocognitive mechanisms of anxiety disorders. In response to limitations and contradictions in the logic of the categorical method of classification of mental disorders, the popularity of the dimensional approach, in which the emphasis shifts to the assessment of the severity of symptoms. The National Institute of Mental Health has developed the promising approach based on the search for systemic neurobiological foundations of mental disorders. Based on the project RDoC (Research Domain Criteria) the search for trans-diagnostic mechanisms of mental disorders has been updated. The logic of RDoC echoes the position of Russian pathopsychology, in which the syndrome of mental activity disorders is considered in dynamics, the mechanisms of the functioning of the psyche are qualified as identical in norm and pathology. In the study of anxiety-related disorders, the obvious commonality of the spectrum of manifestations that acquire nosological clarification against the background of the escalation of the severity of symptoms and secondary compensatory processes has repeatedly been put forward in the center of research attention. The aim of the article is a theoretical and methodological analysis of the neurocognitive basis of the errors monitoring system, characteristic of normal and excessively expressed in anxiety disorders, including ERP component — error related negativity (ERN). As a result, it is shown that this neurocogitive marker, experimentally modeled in conflict tasks (e.g., Eriksen’s flanker task), is expected to be a probable transdiagnostic basis for anxiety-related disorders (social anxiety disorder, obsessive-compulsive disorder). The increase in the amplitude of ERN in internalization, uniting anxiety-depressive symptoms, is explained by individual differences in the readiness to detect error and sensitivity to incorrect decisions. At the moment, the study of ERN retains the “tempted” of simplified interpretations, the arbitrary establishment of direct causal connections between the neural basis and mental phenomena.

Keywords

transdiagnostic neurocognitive mechanisms of anxiety disorders / error related negativity (ERN) / dimensional approach / error monitoring system / social anxiety disorder / obsessive-compulsive disorder

References

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Funding

РФФИRFBR(№17-29-02420)

RIGHTS & PERMISSIONS

Sagalakova O.A., Truevtsev D.V., Zhirnova O.V.