Clinical case of early diagnosis of inflammatory form of cerebral amyloid angiopathy

Elena G. Klocheva , Vitalij V. Goldobin , Nataliya  M. Tertyshnaya , Maryna Osipova

Neurology Bulletin ›› 2019, Vol. LI ›› Issue (4) : 83 -87.

PDF
Neurology Bulletin ›› 2019, Vol. LI ›› Issue (4) : 83 -87. DOI: 10.17816/nb16539
Clinical case reports
research-article

Clinical case of early diagnosis of inflammatory form of cerebral amyloid angiopathy

Author information +
History +
PDF

Abstract

There was presented a clinical case of early recognition of inflammatory form of cerebral amyloid angiopathy in patient with severe diffuse headache, slightly responding to analgetics, and focal signs of pyramidal and cerebellar involvement. Clinical and radiological data were sufficient to make diagnosis of probable inflammatory form of cerebral amyloid angiopathy. Pulse-therapy with methylprednisolone was performed, followed by clinical and MRI data improvement. After 4 month relapse the cephalgia took place again due to viral infection. Pulse-therapy with corticosteroids was repeated with clinical improvement.

 

Keywords

inflammatory form of cerebral amyloid angiopathy / magnetic resonance imaging of brain / multiple microbleeds / asymmetric leucoaraiosis / steroid pulse-therapy

Cite this article

Download citation ▾
Elena G. Klocheva, Vitalij V. Goldobin, Nataliya  M. Tertyshnaya, Maryna Osipova. Clinical case of early diagnosis of inflammatory form of cerebral amyloid angiopathy. Neurology Bulletin, 2019, LI(4): 83-87 DOI:10.17816/nb16539

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Макотрова Т.А., Левин О.С., Араблинский А.В. Церебральная амилоидная ангиопатия. Ж. неврол. и психиатрии. 2014; 6 (2): 87–93. [Makotrova T.A., Levin O.S., Arablinskiy A.V. Cerebral amyloid angiopathy. Zhurnal nevrologii i psychiatrii. 2014; 6 (2): 87–93. (In Russ.)]

[2]

Новосадова О.А., Григорьева В.Н. Церебральная амилоидная ангиопатия и гипертензивная церебральная микроангиопатия. Дифференциальный диагноз. Неврол. вестн. им. В.М. Бехтерева. 2019; LI (2): 72–79. [Novosadova O.A., Grigorjeva V.N. Cerebal amyloid angiopathy and hypertensive cerebral microangiopathy. Differential diagnosis. Nevrologicheskiy vestnik im. V.M. Bekhtereva. 2019; LI (2): 72–79. (In Russ.)]

[3]

Vonsattel J.P., Myers R.H., Hedley-Whyte E.T. et al. Cerebral amyloid angiopathy without and with cerebral hemorrhages: a comparative histological study. Ann. Neurol. 1991; 30: 637–649.

[4]

Coria F., Rubio I. Cerebral amyloid angiopathies. Neuropathol. Appl. Neurobiol. 1996; 22: 216e27.

[5]

Yamada M. Predicting cerebral amyloid angiopathy-related intracerebralhemorrhages and other cerebrovascular disorders in Alzheimer’s disease. Front. Neurol. Stroke. 2012; 3: 1–7. DOI: 10.3389/fneur.2012.00064.

[6]

Chung K.K., Anderson N.E., Hutchinson D. et al. Cerebral amyloid angiopathy related inflammation: three case reports and a review. J. Neurol. Neurosurg. Psychiatry. 2011; 82 (1): 20–26. DOI: 10.1136/jnnp.2009.204180.

[7]

Scolding N.J., Joseph F., Kirby P.A. et al. Abeta-related angiitis: primary angiitis of the central nervous system associated with cerebral amyloid angiopathy. Brain. 2005; 128: 500–515.

[8]

Melzer N., Harder A., Gross C.C. et al. CD41 T cells predominate in cerebrospinal fluid and leptomeningeal and parenchymal infiltrates in cerebral amyloid beta-related angiitis. Arch. Neurol. 2012; 69: 773–777. DOI: 10.1001/archneurol.2011.2441.

[9]

Eng J.A., Frosch M.P., Choi K. et al. Clinical manifestations of cerebral amyloid angiopathy-related inflammation. Ann. Neurol. 2004; 55 (2): 250–256. DOI: 10.1002/ana.10810.

[10]

DiFrancesco J.C., Brioschi M., Brighina L. et al. Anti-Abeta autoantibodies in the CSF of a patient with CAA-related inflammation: a case report. Neurology. 2011; 76 (9): 842–844. DOI: 10.1212/WNL.0b013e31820e773c.

[11]

Martucci M., Sarria S., Toledo M. et al. Cerebral amyloid angiopathy-related inflammation: imaging findings and clinical outcome. Neuroradiology. 2014; 56 (4): 283–289. DOI: 10.1007/s00234-014-1330-6.

[12]

Auriel E., Charidimou A., Gurol M.E. et. al. Validation of clinicoradiological criteria for the diagnosis of cerebral amyloid angiopathy-related inflammation. JAMA Neurol. 2016; 73 (2): 197–202. DOI: 10.1001/jamaneurol.2015.4078.

[13]

Kirshner H.S., Bradshaw M. The inflammatory form of cerebral amyloid angiopathy or “Cerebral Amyloid Angiopathy-Related Inflammation” (CAARI). Curr. Neurol. Neurosci. Rep. 2015; 15: 54–60. DOI: 10.1007/s11910-015-0572-y.

[14]

Piazza F., Greenberg S.M., Savoiardo M. et al. Anti-amyloid beta autoantibodies in cerebral amyloid angiopathy-related inflammation: implications for amyloid-modifying therapies. Ann. Neurol. 2013; 73 (4): 449–458. DOI: 10.1002/ana.23857.

RIGHTS & PERMISSIONS

Klocheva E.G., Goldobin V.V., Tertyshnaya N.M., Osipova M.

AI Summary AI Mindmap
PDF

135

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/