THE ROLE OF THE BRAIN NEUROTROPHIC FACTOR IN DEVELOPMENT OF THE DIABETIC FOOT SYNDROME

Abstract

The quantitative content of brain neurotrophic factor in the serum of patients at the late stage of diabetic polyneuropathy was studied. Clinical and neurophysiological signs of moderate and severe diabetic neuropathy correlated with serum levels of brain neurotrophin were revealed. In patients with diabetic foot syndrome, there is a pronounced BDNF deficiency, which reflects a violation of the compensatory recovery capabilities of the nervous system. The depletion of brain neurotrophin at a late stage requires further study of the pathogenesis of diabetic neuropathy from the standpoint of neuroplasticity to improve the timely diagnosis and prevention of diabetic foot syndrome.

Keywords

diabetic neuropathy / diabetic foot syndrome / electroneuromyographic study / brain neurotrophic factor / neuroplasticity

References

[1] Каракулова Ю.В., Селянина Н. В. Мониторирование нейротрофических факторов и когнитивных функций у пациентов с черепно-мозговой травмой // Журнал неврологии и психиатрии им. С.С. Корсакова. 2017. Т. 117(10). С. 34-37.

[2] Rabasseda X. A report from the 74th American Diabetes Association Scientific Sessions (May 13-17 - San Francisco, California, USA) // Drugs Today. 2014. Vol. 50(8). P. 579

RIGHTS & PERMISSIONS

Filimonova T.A., Karakulova Y.V.