POLYMORPHIC VARIANTS DRD4 DOPAMINE RECEPTOR GENE AMONG CONSUMERS AND NON-CONSUMERS OF SYNTHETIC CATHINONE

Abstract

We have analyzed DRD4 120bp VNTR samples provided by 181 patients suffering from cathinone addiction (case 1) and compared them to the samples taken from 168 somatically and psychologically healthy people (case 2). The analysis showed DRD4*L (120bp dup) as the most common allele in both cases. However, the frequency of the genotype *S/*S happened to be statistically more significant in case 1 compared to case 2. Based on this analysis, it could be concluded that the genetic effect on developing an addition to synthetic cathinone can be mediated via dopaminergic system, in particular by DRD4 120bp VNTR.

Keywords

DRD4*L / cathinone / addiction / dopamine receptor / DRD4 * L

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RIGHTS & PERMISSIONS

Asadullin A.R., Yuldashev V.L., Nikolaev I.V., Akhmetova E.A., Khalikov S.A.