MENTAL DISORDERS, PSYCHOLOGICAL CHARACTERISTICS AND MARKERS OF CENTRAL NERVOUS SYSTEM DAMAGE IN PATIENTS UNDERGOING CARDIAC SURGERY WITH EXTRACORPOREAL CIRCULATION
Natalya N Petrova , Rada S Kovaltsova , Vladimir V Dorofeykov , Olga N Mashek , Andrei E Bautin , Dmitry M Tashkhanov
Neurology Bulletin ›› 2016, Vol. XLVIII ›› Issue (3) : 18 -24.
MENTAL DISORDERS, PSYCHOLOGICAL CHARACTERISTICS AND MARKERS OF CENTRAL NERVOUS SYSTEM DAMAGE IN PATIENTS UNDERGOING CARDIAC SURGERY WITH EXTRACORPOREAL CIRCULATION
The article presents data on personal characteristics, features of cognitive and affective disorders in patients having undergone cardiac surgery treatment with extracorporeal circulation. Significant frequency of anxiety and depressive disorders in cardiac patients before surgery in the absence of cognitive impairment was shown. We have examined the relationships of cognitive functioning and the level of NSE and protein S100b. Increased concentration of neuromarkers in the early postoperative period (12-48 hours) in 80-90% of patients was demonstrated. It is shown that normalization of neuromarkers during the first day after surgery is a favorable prognostic factor in restoring cognitive functions of patients. Clinical-and- scale evaluation revealed a positive effect of cardiac surgery treatment on cognitive and emotional sphere of patients at 15 days after surgery.
NSE / affective disorders / cognitive dysfunction / NSE / S100b / extracorporeal circulation
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Petrova N.N., Kovaltsova R.S., Dorofeykov V.V., Mashek O.N., Bautin A.E., Tashkhanov D.M.
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