CLINICAL SIGNIFICANCE OF SILENT CEREBRAL INFARCTIONS IN PATIENTS WITH CEREBROVASCULAR DISEASE AND THEIR CONNECTION WITH COGNITIVE DECLINE

Abstract

Risk factors of cerebral silent infarctions and their influence on state of cognitive functions have been studied in 124 patients, aged 50 -85. In 16 among 63 patients with cerebral silent infarctions there were multiple foci; in 61 patients with chronical cerebral ischemia there were no insults and transitory ischemic attacks in the medical history and data of neurovisualization examination. Neuropsychological test results showed that state of cognitive functions was worse in patients with silent infarctions. The obtained data confirm a negative influence of silent infarctions on cognitive functions’ state and increase the risk of progressing chronical cerebral ischemia.

Keywords

silent insult / cognitive deficit / cerebrovascular diseases / microangiopathy of brain

References

[1] Гусев Е.И., Скворцова В. И. Ишемия головного мозга. М.: Медицина, 2001. 328с

[2] Гусев Е.И., Скворцова В.И., Мартынов М.Ю., Камчатнов П.Р. Церебральный инсульт: проблемы и решения // Вестник РГМУ. 2006. № 4 (51). С. 28-36

[3] Гусев Е.И., Скворцова В.И., Стаховская Л.В. Эпидемиология инсульта в России // Журнал неврологии и психиатрии им. С.С. Корсакова. Инсульт: приложение. 2003. № 8. С. 4-9

[4] Barber R., Scheltens P., Gholkar A. White matter lesions on magnetic resonance imaging in dementia with Lewy bodies, Alzheimer’s disease, vascular dementia, and normal aging // J. Neurol Neurosurg Psychiatry. 1999. Vol. 67. P. 66-72

[5] Bernick C., Kuller L., Dulberg C. Silent MRI infarcts and the risk of future stroke: the cardiovascular health study // Neurology. 2001. Vol. 57. P. 1222-1229

[6] Boss H., van den Berg-Vos R., Scheltens P., Weinstein H. Vascular cognitive impairment // Ned Tijdschr Geneeskd. 2010. Vol. 154. P. A1907

[7] Das R., Seshadri S., Beiser A. Prevalence and correlates of silent cerebral infarcts in the Framingham offspring study // Stroke. 2008. Vol. 39. P. 2929-2935

[8] Feigin V., Forouzanfar, M., Krishnamurthi R., Mensah G., Sacco R. on behalf of the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) and the GBD Stroke Experts Group Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010 // The Lancet. Vol. 383 (9913). P. 245-255

[9] Fisher М. Lacunar infarcts - a review // Cerebrovasc Dis. 1991. Vol.1 P. 311-320

[10] Hasegawa Y., Yamaguchi T., Omae T. et al. Effects of perindopril-based blood pressure lowering and of patient characteristics on the progression of silent brain infarct: the Perindopril Protection against Recurrent Stroke Study (PROGRESS) CT Substudy in Japan // Hypertens Res. 2004. Vol. 27(3). P. 147-156

[11] Kwon H., Kim B., Lee S. Metabolic syndrome as an independent risk factor of silent brain infarction in healthy people // Stroke. 2006. Vol. 37. P. 466-470

[12] Ritter M., Dittrich R., Ringelstein E. Silent brain infarcts // Nervenarzt. 2011. Vol. 82(8). P. 1043-1052

[13] Sato H., Koretsune Y., Fukunami M. et al. Aspirin attenuates the incidence of silent brain lesions in patients with nonvalvular atrial fibrillation // Circ J. 2004. Vol. 68(5). P. 410-416

[14] Scheltens P., Barkhof F., Leys D. et al. A semiquantita-tive rating scale for the assessment of signal hyperintensities on magnetic resonance imaging // J. Neurol Sci. 1993. Vol. 114. P. 7-12

[15] Skoog I., Nilsson L., Palmertz B. et al. A population-based study of dementia in 85-yearolds // N. Engl J. Med 1993. Vol. 328. P. 153-158

[16] Song I., Kim J., Kim Y. et al. Clinical significance of silent cerebral infarctions in patients with Alzheimer disease // Cogn Behav Neurol. 2007. Vol. 20(2). P. 93-98

[17] van Swieten J., Hijdra A., Koudstaal P., van Gijn J. Grading white matter lesions on CT and MRI: a simple scale // J. Neurol Neurosurg Psychiatry. 1990. Vol. 53. P. 1080-1083

[18] Vermeer S., Prins N., den Heijer T. et al. Silent brain infarcts and the risk of dementia and cognitive decline // N. Engl. J. Med. 2003. Vol. 348. P. 1215-1222

[19] Vermeer S., Longstreth W. Jr, Koudstaal P. Silent brain infarcts: a systematic review // Lancet Neurol. 2007. Vol. 6. P. 611-619

[20] Wardlaw J., Smith E., Biessels. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration // Lancet Neurol. 2013. Vol. 12(8). P. 822-838

[21] Zhefeng Q., Bokura H., Iijima K. The influences of silent cerebral infarction and hypertension on brain atrophy in normal adults // Nihon Ronen Igakkai Zasshi. 2008. Vol. 45(2). P. 175-181

RIGHTS & PERMISSIONS

Zhetishev R.R., Kamchatnov P.R., Mihailova N.A., Ivashchenko R.A.