NEUROPROTECTIVE EFFECT OF ENDACANNABINOID N-ARACHIDONOYLDOPAMINE IN ACUTE HYPOBARIC HYPOXIA

Elena V Mitroshina; Maria V Vedunova; Andrei A Mironov; Tatyana A Saharnova; Alexei S Pimashkin; Mikhail Y Bobrov; Leonid G Khaspeckov; Irina V Mukhin

doi:10.17816/nb13724

Neurology Bulletin ›› 2012, Vol. XLIV ›› Issue (1) : 14 -19. DOI: 10.17816/nb13724

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NEUROPROTECTIVE EFFECT OF ENDACANNABINOID N-ARACHIDONOYLDOPAMINE IN ACUTE HYPOBARIC HYPOXIA

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1) Nizhny Novgorod State Medical Academy, 2)The N.I. Lobachevsky Nizhny Novgorod State University

1) Nizhny Novgorod State Medical Academy

2)The N.I. Lobachevsky Nizhny Novgorod State University

1) Nizhny Novgorod State Medical Academy, 2)The N.I. Lobachevsky Nizhny Novgorod State University

The N.I. Lobachevsky Nizhny Novgorod State University

1) Institute of biochemistry, named after academicians М.М. Shemyakin and Yu. A. Оvchinnikov, RAS

2) State Institution Scientific Neurology centre of RAMS

State Institution Scientific Neurology centre of RAMS

1) Nizhny Novgorod State Medical Academy

2)The N.I. Lobachevsky Nizhny Novgorod State University

2) Нижегородский государственный университет им Н.И. Лобачевского

1) Nizhny Novgorod State Medical Academy, 2)The N.I. Lobachevsky Nizhny Novgorod State University

1) Nizhny Novgorod State Medical Academy; 2)The N.I. Lobachevsky Nizhny Novgorod State University

1) Nizhny Novgorod State Medical Academy, 2)The N.I. Lobachevsky Nizhny Novgorod State University

The N.I. Lobachevsky Nizhny Novgorod State University

1) Institute of biochemistry, named after academicians М.М. Shemyakin and Yu. A. Оvchinnikov, RAS; 2) State Institution Scientific Neurology centre of RAMS

State Institution Scientific Neurology centre of RAMS

1) Nizhny Novgorod State Medical Academy; 2)The N.I. Lobachevsky Nizhny Novgorod State University

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Abstract

The effect of the endogenous cannabinoid N-arachi-donoyldopamin (AA-DA) in acute hypobaric hypoxia in mice was studied. The lifetime of the animals at the height, survival, changes in locomotor activity with the test «open field» and the long-term memory with test «Morris water maze» were evaluated. It was revealed that injection of AA-DA significantly increased survival animals and long-term memory in remote period of acute hypoxia. Neuroprotective effect of AA-DA was shown.

Keywords

endocannabinoid system / neuroprotection / N-arahidonoildophamin / acute hypobaric hypoxia

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Elena V Mitroshina, Maria V Vedunova, Andrei A Mironov, Tatyana A Saharnova, Alexei S Pimashkin, Mikhail Y Bobrov, Leonid G Khaspeckov, Irina V Mukhin. NEUROPROTECTIVE EFFECT OF ENDACANNABINOID N-ARACHIDONOYLDOPAMINE IN ACUTE HYPOBARIC HYPOXIA. Neurology Bulletin, 2012, XLIV(1): 14-19 DOI:10.17816/nb13724

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