Demyelinating disease in a patient with cerebral venous thrombosis and covid-19 clinical manifestations

Yelena G. Klocheva; Farakhnoz Z. Olimova; Vitalii V. Goldobin; Julia D. Bogatenkova

doi:10.17816/nb104446

Neurology Bulletin ›› 2022, Vol. LIV ›› Issue (2) : 85 -95. DOI: 10.17816/nb104446

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Demyelinating disease in a patient with cerebral venous thrombosis and covid-19 clinical manifestations

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Abstract

Actually, verifying neurological disorders associated with COVID-19 make clinicians ask several questions: the manifestation of neurological pathology is due to COVID-19, or there is a combination of several CNS pathologies with COVID-19. We report a clinical case of a 57-year-old female patient with demyelinating disease of the central nervous system, cerebral venous thrombosis associated with clinically transferred COVID-19. Differential diagnosis was performed with multiple sclerosis, acute multiple encephalomyelitis, opticomyelitis, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, sarcoidosis, antiphospholipid syndrome, mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS) and thrombosis veins of the large hemispheres. Probable pathogenetic variants of demyelination development and possible connection with cerebral venous thrombosis and COVID-19 are highlighted.

Keywords

demyelinating diseases of the central nervous system / cerebral venous thrombosis / COVID-19 / molecular genetic analysis

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Yelena G. Klocheva, Farakhnoz Z. Olimova, Vitalii V. Goldobin, Julia D. Bogatenkova. Demyelinating disease in a patient with cerebral venous thrombosis and covid-19 clinical manifestations. Neurology Bulletin, 2022, LIV(2): 85-95 DOI:10.17816/nb104446

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