ULTRASTRUCTURAL CHARACTERISTICS OF THE ENDOMETRIAL EPITHELIUM DURING THE IMPLANTATION WINDOW IN HEALTHY WOMEN AND IN PATIENTS WITH REPRODUCTIVE FAILURE

O. A. Melkozerova; G. N. Chistyakova; Ye. Ye. Bragina; A. A. Grishkina; I. D. Shchedrina

doi:10.34922/AE.2020.157.1.008

Morphology ›› 2020, Vol. 157 ›› Issue (1) : 48 -54. DOI: 10.34922/AE.2020.157.1.008

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ULTRASTRUCTURAL CHARACTERISTICS OF THE ENDOMETRIAL EPITHELIUM DURING THE IMPLANTATION WINDOW IN HEALTHY WOMEN AND IN PATIENTS WITH REPRODUCTIVE FAILURE

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Abstract

Objective - to study the ultrastructural pattern of endometrial receptivity in healthy women and in patients with reproductive failures. Material and methods. Scanning electron microscopy of the endometrial epithelium was performed in 119 patients with uterine factor infertility and miscarriage due to endometrial hypoplasia. Results. Ultramorphological picture of the epithelium of decidua in patients with infertility was characterized by aplasia and hypoplasia of pinopodia (67.39 %), tight junctions (69,53 %), and heteromorphy of secretory cells (15,22 %) in combination with atypia of cells of microenvironment (50 %). In patients with miscarriage, asynchronous development of pinopodia (46,67 %) and the lack of separation of intercellular contacts during the implantation window period (84,44 %) were noted. Conclusion. The revealed abnormalities determine the mechanisms of impaired blastocyst adhesion and trophoblast invasion at different stages of implantation in patients with uterine factor infertility and miscarriage.

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endometrium / pinopodia / uterine factor infertility

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O. A. Melkozerova, G. N. Chistyakova, Ye. Ye. Bragina, A. A. Grishkina, I. D. Shchedrina. ULTRASTRUCTURAL CHARACTERISTICS OF THE ENDOMETRIAL EPITHELIUM DURING THE IMPLANTATION WINDOW IN HEALTHY WOMEN AND IN PATIENTS WITH REPRODUCTIVE FAILURE. Morphology, 2020, 157(1): 48-54 DOI:10.34922/AE.2020.157.1.008

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