MORPHOMETRIC CHARACTERISTIC OF HISTOARCHITECTONICS OF THE HUMAN SPLEEN

Abstract

Objective - to determine the characteristic features of the human spleen histoarchitectonics in correlation with the main stages of the immune response. Material and methods. The work was performed on the autopsy material of spleen taken from 20 people, who had no history of the pathology of the hematopoietic system. The median age was 39 (27; 65) years. Histological, immunohistochemical, and morphometric study of white and red pulp areas and cellular composition of spleen at different stages of immune response was carried out. Results. It was found that changes in the morphometric para­meters of white and red pulp, as well as its components, depended on the degree of activity of the immune processes that occur in tissue compartments of the spleen at various stages of the immune response. Differences in the content of cellular elements in the functional zones of the organ were revealed. Conclusions. To study the histoarchitectonics of the spleen, it is important to take into account the specifics of the migration of cellular elements, the dynamics and abundance of their distribution in white and red pulp at the main stages of the immune response, which undoubtedly affects the mass of the organ and, accordingly, its functional compartments. The results can be used to analyze the histoarchitectonics of the spleen and study its cellular composition in the diagnosis of diseases causing damage to the organs of the immune system.

Keywords

spleen / morphometry / immunohistochemistry

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RIGHTS & PERMISSIONS

Fedorovskaya N.S., Zheleznov L.M., Zaitsev V.B., Diakonov D.A., Koledaeva Y.V.