Differences in the functional activity of human neutrophilic granulocytes in their interactions with semiconductor quantum dots

S N PLESKOVA; I V BALALAYEVA; Yu Yu GUSHCHINA; Ye A SERGEYEVA; T A ZDOBNOVA; S M DEYEV; I V TURCHIN

doi:10.17816/morph.402478

Morphology ›› 2009, Vol. 135 ›› Issue (3) : 47 -49. DOI: 10.17816/morph.402478

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Differences in the functional activity of human neutrophilic granulocytes in their interactions with semiconductor quantum dots

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RAS Institute of Applied Physics, Nizniy NovgorodScientific-Educational Center of Solid State Nanostructure Physics, N.I. Lobachevskiy Nizniy Novgorod State UniversityM.M. Shemyakin and I.Yu. Ovchinnikov Institute of Bioorganic Chemistry, Moscow

Лаборатория биофотоники; Институт прикладной физики РАН, г. Нижний НовгородНаучно-образовательный центр физики твердотельных наноструктур Нижегородского государственного университета им. Н.И. Лобачевского; RAS Institute of Applied Physics, Nizniy NovgorodScientific-Educational Center of Solid State Nanostructure Physics, N.I. Lobachevskiy Nizniy Novgorod State UniversityM.M. Shemyakin and I.Yu. Ovchinnikov Institute of Bioorganic Chemistry, Moscow

Лаборатория биофотоникикафедра биофизики; Институт прикладной физики РАН, г. Нижний НовгородНижегородский государственный университет им. Н.И. Лобачевского; RAS Institute of Applied Physics, Nizniy NovgorodScientific-Educational Center of Solid State Nanostructure Physics, N.I. Lobachevskiy Nizniy Novgorod State UniversityM.M. Shemyakin and I.Yu. Ovchinnikov Institute of Bioorganic Chemistry, Moscow

Лаборатория биофотоники; Научно-образовательный центр физики твердотельных наноструктур Нижегородского государственного университета им. Н.И. Лобачевского; RAS Institute of Applied Physics, Nizniy NovgorodScientific-Educational Center of Solid State Nanostructure Physics, N.I. Lobachevskiy Nizniy Novgorod State UniversityM.M. Shemyakin and I.Yu. Ovchinnikov Institute of Bioorganic Chemistry, Moscow

Лаборатория биофотоники; Институт прикладной физики РАН, г. Нижний Новгород; RAS Institute of Applied Physics, Nizniy NovgorodScientific-Educational Center of Solid State Nanostructure Physics, N.I. Lobachevskiy Nizniy Novgorod State UniversityM.M. Shemyakin and I.Yu. Ovchinnikov Institute of Bioorganic Chemistry, Moscow

Лаборатория биофотоникилаборатория молекулярной иммунологии; Институт прикладной физики РАН, г. Нижний НовгородИнститут биоорганической химии им. акад. М.М. Шемякина и Ю.А. Овчинникова, Москва; RAS Institute of Applied Physics, Nizniy NovgorodScientific-Educational Center of Solid State Nanostructure Physics, N.I. Lobachevskiy Nizniy Novgorod State UniversityM.M. Shemyakin and I.Yu. Ovchinnikov Institute of Bioorganic Chemistry, Moscow

лаборатория молекулярной иммунологии; Институт биоорганической химии им. акад. М.М. Шемякина и Ю.А. Овчинникова, Москва; RAS Institute of Applied Physics, Nizniy NovgorodScientific-Educational Center of Solid State Nanostructure Physics, N.I. Lobachevskiy Nizniy Novgorod State UniversityM.M. Shemyakin and I.Yu. Ovchinnikov Institute of Bioorganic Chemistry, Moscow

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Abstract

The uptake of quantum dots (QD - 5 nm particles of CdSe/ ZnS-mercaptoacetic acid) by human neutrophilic granulocytes was studied using the methods of scanning laser and scanning probe microscopy. The results show that the neutrophilic granulocytes may be subdivided into three subpopulations: 1) the cellswith no uptake of QD (10.0±2.0%); 2) cells that accumulateQD in their volume (28.0±1.9%), and 3) cells, surrounded by a halo of QD (59.0±2.2%). The dispersion of these characteristics may suggest the differences in neutrophilic granulocyte plasma membrane permeability.

Keywords

neutrophilic granulocytes / semiconductor quantum dots / scanning laser microscopy / scanning probe microscopy

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S N PLESKOVA, I V BALALAYEVA, Yu Yu GUSHCHINA, Ye A SERGEYEVA, T A ZDOBNOVA, S M DEYEV, I V TURCHIN. Differences in the functional activity of human neutrophilic granulocytes in their interactions with semiconductor quantum dots. Morphology, 2009, 135(3): 47-49 DOI:10.17816/morph.402478