Differences in the functional activity of human neutrophilic granulocytes in their interactions with semiconductor quantum dots
S N PLESKOVA , I V BALALAYEVA , Yu Yu GUSHCHINA , Ye A SERGEYEVA , T A ZDOBNOVA , S M DEYEV , I V TURCHIN
Morphology ›› 2009, Vol. 135 ›› Issue (3) : 47 -49.
Differences in the functional activity of human neutrophilic granulocytes in their interactions with semiconductor quantum dots
The uptake of quantum dots (QD - 5 nm particles of CdSe/ ZnS-mercaptoacetic acid) by human neutrophilic granulocytes was studied using the methods of scanning laser and scanning probe microscopy. The results show that the neutrophilic granulocytes may be subdivided into three subpopulations: 1) the cellswith no uptake of QD (10.0±2.0%); 2) cells that accumulateQD in their volume (28.0±1.9%), and 3) cells, surrounded by a halo of QD (59.0±2.2%). The dispersion of these characteristics may suggest the differences in neutrophilic granulocyte plasma membrane permeability.
neutrophilic granulocytes / semiconductor quantum dots / scanning laser microscopy / scanning probe microscopy
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