EPIDERMAL THICKNESS AND KERATINOCYTE PROLIFERATION AFTER CUTANEOUS APPLICATION OF VITAMIN D 3

S. A. Zhuchkov; T. A. Belousova; V. I. Nozdrin

doi:10.17816/morph.399621

Morphology ›› 2012, Vol. 142 ›› Issue (6) : 056 -060. DOI: 10.17816/morph.399621

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EPIDERMAL THICKNESS AND KERATINOCYTE PROLIFERATION AFTER CUTANEOUS APPLICATION OF VITAMIN D 3

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Abstract

Using light microscopy, morphometry and immunohistochemistry, the epidermis of 72 male and female rats was examined 1 day and 1 month after the completion of daily cutaneous applications of vitamin D 3–containing composition lasting for two weeks. It was found that vitamin D3 causes a statistically significant reduction in the thickness of interfollicular epidermis and in the number of Ki-67 positive keratinocytes. The identified effects persisted for 1 month after the last application of the preparation. Modifying influence of vitamin D 3 on the morphogenetic processes in the epidermis, which were manifested, in particular, by a decreased proliferative activity of keratinocytes, is discussed in the light of the data on the possibility of the formation of its active metabolite – calcitriol – directly in the skin.

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epidermis / proliferation / keratinocytes / vitamin D / calcitriol

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S. A. Zhuchkov, T. A. Belousova, V. I. Nozdrin. EPIDERMAL THICKNESS AND KERATINOCYTE PROLIFERATION AFTER CUTANEOUS APPLICATION OF VITAMIN D 3. Morphology, 2012, 142(6): 056-060 DOI:10.17816/morph.399621

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