RAT BRAIN CELLS CONTAINING EZRIN (CYTOVILLIN)

D E Korzhevskiy; O V Kirik; A V Gilyarov; D E Korzhevskiy; O V Kirik; A V Giliarov

doi:10.17816/morph.399583

Morphology ›› 2011, Vol. 140 ›› Issue (6) : 86 -88. DOI: 10.17816/morph.399583

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RAT BRAIN CELLS CONTAINING EZRIN (CYTOVILLIN)

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Abstract

Ezrin (cytovillin or p81 protein) is an actin-binding protein, a member of ERM (ezrin, radixin and moesin) family, which species contribute to stabilization of the plasma membrane-formed structures. The aim of the present study was to demonstrate the ezrin-containing cells in the rat brain and to describe their topography and morphological features. The most pronounced immunohistochemical reaction to ezrin was found in the epithelium of the choroid plexus, cells of the subcommissural organ and ventricular ependyma. Moreover, ezrin staining was also detected in the unidentifiable cells in the subventricular zone, rostral migration pathway and astrocytes in various brain areas. Preferential ezrin localization in the brain cells contributing to formation of barrier structures suggests its involvement in transport processes in the CNS.

Keywords

brain / ezrin / blood-brain barrier / choroid plexus / astrocytes

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D E Korzhevskiy, O V Kirik, A V Gilyarov, D E Korzhevskiy, O V Kirik, A V Giliarov. RAT BRAIN CELLS CONTAINING EZRIN (CYTOVILLIN). Morphology, 2011, 140(6): 86-88 DOI:10.17816/morph.399583

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References

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[1]	Коржевский Д.Э. Сосудистое сплетение головного мозга и структурная организация гематоликворного барьера у человека. Региональное кровообращение и микроциркуляция, 2003, т. 2, № 1(5), с. 5-14.

[2]	Коржевский Д.Э. Нейрогенез и нейральные стволовые клетки. Мед. акад. журн., 2010, т. 10, № 4, с. 175-182.

[3]	Bretscher A., Reczek D. and Berryman M. Ezrin: a protein requiring conformation activation to link microfilaments to the plasma membrane in the assembly of cell surface structure. J. Cell Sci., 1997, v. 110, p. 3011-3018.

[4]	Geiger K.D., Stoldt P., Schlote W. and Derouiche A. Ezrin immunoreactivity reveals specific astrocyte activation in cerebral HIV. J. Neuropathol. Exp. Neurol., 2006, v. 65, № 1, P. 87-96.

[5]	Johnson M.W., Miyata H. and Vinters H.V. Ezrin and moesin expression within the developing human cerebrum and tuberous sclerosis-associated cortical tubers. Acta Neuropathol., 2002, v. 104, № 2, P. 188-196.

[6]	Kim W.Y., Shin S.R., Kim S. et al. Cocaine regulates ezrin-radixinmoesin proteins and RhoA signaling in the nucleus accumbens. Neuroscience, 2009, v. 163, № 2, p. 501-505.