DYNAMICS OF HEPATOCYTE PLOIDY CHANGES AFTER MECHANICAL INJURY OF THE FETAL LIVER UNDER THE CONDITIONS OF APPLICATION OF BIOLOGICALLY ACTIVE DRUGS «TREPEL» AND «SUVAR»
L P Romanova , I I Malyshev , L P Romanova , I I Malyshev
Morphology ›› 2012, Vol. 141 ›› Issue (1) : 52 -55.
DYNAMICS OF HEPATOCYTE PLOIDY CHANGES AFTER MECHANICAL INJURY OF THE FETAL LIVER UNDER THE CONDITIONS OF APPLICATION OF BIOLOGICALLY ACTIVE DRUGS «TREPEL» AND «SUVAR»
The aim of this study was to evaluate the effect of biologically active drugs (BAD) «Trepel» and «Suvar» on the hepatocyte ploidy during the restoration of liver structure in rat fetuses and newborn pups after mechanical injury, inflicted on days 16-17 of intrauterine development (n=112), and to determine the association of polyploidization with the other manifestations of regeneration. It was found that during the healing of mechanical liver injury in fetuses and newborn rat pups, along with hepatocytes proliferation, their polyploidization occured. This suggests that polyploidization is one of manifestations of a regenerative process. This study has also shown that BAD «Trepel» and «Suvar» activated both hepatocyte proliferation and their polyploidization. The authors believe that the stimulating effect of these substances is associated with their growth-stimulating effect which results in the change in hormonal status of rat organism.
liver / regeneration / polyploidization mechanical trauma / fetuses and newborns
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