STRESS-INDUCED EXPERIMENTAL MYOCARDIAL CHANGES
V S Vasilenko , V S Vasilenko
Morphology ›› 2011, Vol. 140 ›› Issue (6) : 56 -59.
STRESS-INDUCED EXPERIMENTAL MYOCARDIAL CHANGES
Morphological changes in myocardium resulting from experimental stress loads were investigated. Experiment model: group 1 - unloaded swimming (30 rats), group 2 - loaded swimming (30 rats), group 3 - control animals (30 rats - no swimming, maintenance in vivarium). The experimental groups were further divided into 4 subgroups: 1A (adapted animals, n=20), 1NA (unadapted animals, n=10), 2A (adapted animals, n=13), 2NA (unadapted animals, n=17). Histological study of myocardium in subgroups 2A, 1NA and 2NA demonstrated dystrophic changes that were either moderate (subgroups 2A and 1NA) or expressed (subgroup 2NA). Foci of interstitial edema and perivascular hemorrhages were detected. In subgroups 1NA and 2NA, cardiomyocyte cross striation disappeared, cell cytoplasm became vacuolated, foci of cardiomyocyte destruction and necrosis were present. The degree of myocardial changes was found to depend upon stress intensity and individual tolerance of rats. Computer morphometry was unable to detect any significant differences in the thickness of cardiomyocyte fibers between the subgroups.
myocardium / physical loads / stress / dystrophic changes / rats
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