NEURAL STEM CELL MARKER MSI-1 EXPRESSION IN RAT TELENCEPHALON
O V Kirik , O S Alekseeva , D E Korzhevskiy , O V Kirik , O S Alekseyeva , D E Korzhevskiy
Morphology ›› 2011, Vol. 139 ›› Issue (2) : 77 -79.
NEURAL STEM CELL MARKER MSI-1 EXPRESSION IN RAT TELENCEPHALON
The aim of the study was to examine the distribution of cells expressing Msi-1 (Musashi-1) protein which is believed to be a marker of neural stem cells, in rat telencephalon. These cells were found to be concentrated in the subventricular proliferative zone and diffusely scattered in striatum and hippocampus. Moreover, neurons with extensive Msi-1 reaction were found in habenular nuclei. The data obtained are not in full agreement with current views on the localization of neural stem cells in the brain.
brain / neural stem cells / Msi-1 protein
| [1] |
Коржевский Д.Э. Нейрогенез и нейральные стволовые клетки. Мед. акад. журн., 2010, т. 10, № 4, с. 175-182. |
| [2] |
Коржевский Д.Э., Ленцман М.В., Гиляров А.В. и др. Индукция синтеза нестина в клетках головного мозга крысы под влиянием ишемического повреждения. Морфология, 2007, т. 131, вып. 1, с. 23-26. |
| [3] |
Chojnacki A.K., Mak G.K. and Weiss S. Identity crisis for adult periventricular neural stem cells: Subventricular zone astrocytes, ependimal cells or both? Nat. Rev. Neurosci., 2009, v. 10, № 2, p. 153-163. |
| [4] |
Sakakibara S., Nakamura Y., Satoh H. and Okano H. RNAbinding protein Musashi2: Developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS. J. Neurosci., 2001, v. 21, № 20, p. 8091-8207. |
| [5] |
Yagita Y., Kitagawa K, Sasaki T. et al. Differential expression of Musashi 1 and nestin in the adult rat hippocampus after ischemia. J. Neurosci. Res., 2002, v. 69, № 6, p. 750-756. |
| [6] |
Zheng T., Marshall G.P., Laywell E.D. and Steindler D.A. Neurogenic astrocytes transplanted into the adult mouse lateral ventricle contribute to olfactory neurogenesis, and reveal a novel intrinsic subependymal neuron. Neuroscience, 2006, v. 142, № 1, p. 175-185. |
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