CHANGES THE TRPV1-IMMUNOREACTIVE NEURONS OF RAT SPINAL NERVE SENSORY GANGLIA INDUCED BY CAPSAICIN TREATMENT

V V Porseva; V V Shilkin; M B Korzina; A A Korobkin; P M Maslyukov; V V Porseva; V V Shilkin; M B Korzina; A A Korobkin; P M Maslyukov

doi:10.17816/morph.399492

Morphology ›› 2011, Vol. 139 ›› Issue (3) : 41 -45. DOI: 10.17816/morph.399492

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CHANGES THE TRPV1-IMMUNOREACTIVE NEURONS OF RAT SPINAL NERVE SENSORY GANGLIA INDUCED BY CAPSAICIN TREATMENT

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Abstract

Morphological features of the TRPV1-immunoreactive neurons were studied in thoracic spinal nerve sensory ganglion in 10-, 20-, 30-, 60- and 90-day-old rats under normal conditions and after chemical deafferentation caused by capsaicin (100 mg/kg) subcutaneous injection at postnatal day 2. TRPV1immunoreactive neurons differed in their morphometric characteristics: positive neurons had very small and small sizes, negative cells had the small, medium and large sizes. Capsaicin treatment of newborn rats was shown to change age dynamics of TRPV1-positive neurons resulting in the reduction of the average cell cross-sectional area and cell numbers during the whole period of observation.

Keywords

spinal nerve sensory ganglion / TRPV1- immunopositive neurons / capsaicin / ontogenesis / rat

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V V Porseva, V V Shilkin, M B Korzina, A A Korobkin, P M Maslyukov, V V Porseva, V V Shilkin, M B Korzina, A A Korobkin, P M Maslyukov. CHANGES THE TRPV1-IMMUNOREACTIVE NEURONS OF RAT SPINAL NERVE SENSORY GANGLIA INDUCED BY CAPSAICIN TREATMENT. Morphology, 2011, 139(3): 41-45 DOI:10.17816/morph.399492

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