CHANGES OF THYMOCYTE DIFFERENTIATION, PROLIFERATION AND APOPTOSIS INDUCED BY SYNTETIC PEPTIDES

A A Yarilin; V Kh Khavinson; V O Polyakova; N S Lin'kova; I M Kvetnoy; A A Yarilin; V Kh Khavinson; V O Polyakova; N S Linkova; I M Kvetnoy

doi:10.17816/morph.399485

Morphology ›› 2011, Vol. 140 ›› Issue (4) : 23 -26. DOI: 10.17816/morph.399485

Articles

other

CHANGES OF THYMOCYTE DIFFERENTIATION, PROLIFERATION AND APOPTOSIS INDUCED BY SYNTETIC PEPTIDES

Author information +

History +

PDF

Abstract

The changes in the processes of differentiation, proliferation and apoptosis were studied in the culture of human cortical thymocytes after cell exposure to T-32 and T-38 bioregulator peptides. T-32 and T-38 peptides were shown to enhance the differentiation of immature cortical thymocytes (CD4+CD8+) into T-regulatory cells by increasing their proliferate activity and decreasing the level of apoptosis. Moreover, these peptides were found to stimulate the proliferative and antiapoptotic activity of mature T-regulatory (CD4+CD25+) cells.

Keywords

thymocytes / differentiation / proliferation / apoptosis / peptides

Cite this article

Download citation ▾

A A Yarilin, V Kh Khavinson, V O Polyakova, N S Lin'kova, I M Kvetnoy, A A Yarilin, V Kh Khavinson, V O Polyakova, N S Linkova, I M Kvetnoy. CHANGES OF THYMOCYTE DIFFERENTIATION, PROLIFERATION AND APOPTOSIS INDUCED BY SYNTETIC PEPTIDES. Morphology, 2011, 140(4): 23-26 DOI:10.17816/morph.399485

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Кветной И.М., Ярилин А.А., Полякова В.О. и Князькин И.В. Нейроиммуноэндокринология тимуса. СПб., Деан, 2005.

[2]	Полякова В.О. и Кветной И.М. Тимус и старение (нейроиммуноэндокринные механизмы). СПб., Система, 2004.

[3]	Трофимова С.В., Максимов И.Б. и Нероев В.В. Регуляторное действие пептидов сетчатки. СПб., Коста, 2004.

[4]	Хавинсон В.Х. Пептидная регуляция старения. СПб., Наука, 2009.

[5]	Хавинсон В.Х. и Анисимов В.Н. Пептидные биорегуляторы и старение. СПб., Наука, 2003.

[6]	Хавинсон В.Х., Рыбакина Е.Г. и Малинин В.В. Влияние коротких пептидов на реакцию бласттрансформации тимоцитов и процесс сигнальной трансдукции по сфингомиелиновому пути. Бюлл. экспер. биол., 2002, т. 133, № 5, с. 574-577.

[7]	Ярилин А.А. и Беляков И.М. Тимус как орган эндокринной системы. Иммунология, 1996, № 1, с. 4-10.

[8]	Anisimov V.N. and Khavinson V.Kh. Peptide bioregulation of aging: results and prospects. Biogerontology, 2010, v. 11, p. 139.

[9]	Khavinson V.Kh. and Malinin V.V. Gerontological aspects of genome peptide regulation. Basel, Karger AG, 2005.

[10]	Khavinson V.Kh. and Morozov V.G. Peptides of pineal gland and thymus prolong human life. Neuroendocrinol. Lett., 2003, v. 24, № 3-4, p. 233-240.

[11]	Kvetnoy I.M., Hernandez-Yago J., Hernandez J.M. et al. Diffuse neuroendocrine system and mitochondrial diseases: molecular and cellular bases of pathogenesis, new approaches to diagnosis and therapy. Neuroendocrinol. Lett., 2000, v. 21, v. 2, p. 83-99.

[12]	Kvetnoy I.M., Polyakova V.O., Trofimov A.V. et al. Hormonal function and proliferative activity of thymic cells in humans: immunocytochemical correlations. Neuroendocrinol. Lett., 2003, v. 24, p. 263-268.

[13]	Yamamoto T., Morita S. and Go R. Clonally expanding thymocytes having lineage capability in gamma-ray-induced mouse atrophic thymus. Int. J. Radiat. Oncol. Biol. Phys., 2010, v. 77, № 1, p. 235-243.