PECULIARITIES OF GERMINAL CENTER CYTOARCHITECTONICS IN LYMPHOID NODULES OF RAT MESENTERIC LYMPH NODES AFTER THE EXPOSURE TO AN ACUTE STRESS

Abstract

The purpose of this work was to study the processes of recovery occurring in the germinal centers of lymphoid nodules in the mesenteric lymph node cortex, after the exposure to an acute emotional stress. The experiments were conducted on male Wistar rats, which were divided into the groups of behaviorally active (stress-resistant) and passive (stress-prone) animals, using the «Open field» test. As a model of acute emotional stress, 1-hour-long immobilization of the animals in plexiglass boxes with a simultaneous electrical stimulation of the back, was used. The most pronounced changes in cellular composition of the zones studied occurred during the acute period of stress, as compared to those at 1, 3, 7 and 14 days after the exposure. In behaviorally active rats, the increase in the number lymphoid cells was observed at day 1 following the cessation of stress, while in stress-prone rats, it was found at day 7.

Keywords

mesenteric lymph nodes / lymphoid nodules / germinal centers / emotional stress

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