NEUROTRANSMITTER COMPOSITION INTHE RAT SUPERIOR CERVICAL AND CELIACSYMPATHETIC GANGLIA NEURONS DURING THE POSTNATAL DEVELOPMENT

Abstract

Neurotransmitter composition of the superior cervical ganglion (SCG) and celiac ganglia (CG) neurons was studied immunohis-tochemically in rats of different ages (newborns, 10-, 12-, 30 and 60-days old). The results obtained indicate that the majority of the neurons in these sympathetic ganglia were tyrosine hydroxylase (TH)-positive from birth onwards. Most of TH-positive neurons were also neuropeptide Y-positive. The percentage of neurons containing neuropeptide Y increased with age from birth till the end of the first month in all the ganglia studied. In the CG, the proportion of neuropeptide Y-positive neurons was significantly greater than in SCG. Only single neurons containing substance P, vasoactive intestinal polypeptide (VIP) and choline acethyl transferase (ChAT) were found in both SCG and CG since the moment of birth. The number of these cells remained unchanged with age. The definitive establishment of the neurotransmitter composition in the sympathetic ganglia studied was complete by the end of the first month of life.

Keywords

sympathetic nervous system / superior cervical ganglion / celiac ganglia / immunohistochemistry / ontogenesis

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