Intracerebral progression of transplanted rat C6 glioblastoma cells pretreated with neuropeptides and МАРК inhibitor

Abstract

The authors have monitored C6 glioma cell invasive growth, proliferation and transcriptional regulation after pretreatment with endothelin-1 and ERK1/2 specific inhibitor PD9S059. To explore proliferation of C6 glioma cells in different growth conditions, they were treated in vitro with endothelin-1 and implanted into the brain. In vitro studies have indicated that PD9S059 inhibited the proliferation of cultured C6 glioma cells and induced the activation of E2F1 and Мус-Max transcriptional factors. Endothelin-1 strongly increased C6 glioma cell prolif-eration. The model used in this study is experimental, but it may provide an insight into the specific behavior of in vitro cultured invasive cells.

Keywords

glioma cells / proliferation / transplantation

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