ULTRASTRUCTURE OF OPTIC NERVE FIBERS IN RABBITS AFTER INTRAVITREAL INFUSION OF PERFLUOROORGANIC COMPOUNDS

A N KULIKOV; T A BRAGINA; S V LEPNEVA; E V BOIKO

doi:10.17816/morph.398987

Morphology ›› 2006, Vol. 129 ›› Issue (3) : 37 -40. DOI: 10.17816/morph.398987

Articles

other

ULTRASTRUCTURE OF OPTIC NERVE FIBERS IN RABBITS AFTER INTRAVITREAL INFUSION OF PERFLUOROORGANIC COMPOUNDS

Author information +

History +

PDF

Abstract

Ultrastructure of optic nerve myelinated fibers after intravitreal infusion of perfluorooctylbromide (PFOB) and perfluorodecaline (PFD) for 30 days was studied in rabbits (n = 14). After inraocular administration of PFOB, the ultrastructural changes of optic nerve fibers were mainly reactive in nature. Mitochondrial swelling and partial destruction of cristae were detected in the axons. After PFD infusion, the changes were observed that were not only reactive, but highly degenerative, including destruction of organelles and myelin sheath and axon cytoskeleton disintegration. Thus, the changes associated with PFOB were less pronounced than those found after PFD application. Therefore, PFOB is more promising for the use as an ophthalmologic implant.

Keywords

optic nerve / axons / electron microscopy / fluorocarbons / artificial implants

Cite this article

Download citation ▾

A N KULIKOV, T A BRAGINA, S V LEPNEVA, E V BOIKO. ULTRASTRUCTURE OF OPTIC NERVE FIBERS IN RABBITS AFTER INTRAVITREAL INFUSION OF PERFLUOROORGANIC COMPOUNDS. Morphology, 2006, 129(3): 37-40 DOI:10.17816/morph.398987

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Иванова В.Ф., Михеева Е.А., Карелина В.Е. и Алексеев В.Н. Строение зрительного нерва при экспериментальной глаукоме и некоторых способах ее лечения. Морфология, 2000, т. 117, вып. 2, с. 56-61.

[2]	Кудлачев А.В. и Отеллин В.А. Перспективы клинического использования результатов современных нейроморфологических исследований повреждений и атрофий зрительного нерва. Морфология, 2003, т. 123, вып. 3, с. 94-102.

[3]	Куликов А.Н. Экспериментальное изучение высокочистых жидких перфторорганических соединений при интравитреальном введении: Автореф. дис. ... канд. мед. наук. СПб., 1997.

[4]	Budde M. Silicone oil-associated optic nerve degeneration. Am. J. Ophthalmol., 2001, v. 131, № 3, p. 392-394.

[5]	Mietz H., Prager T., Schweitzer C.et al. Effect of mitomycin C on the optic nerve in rabbits. Br. J. Ophthalmol., 1997, v. 81, №7, p. 584-589.

[6]	Ng E., Joo M., Au Eong K.et al. Ocular toxicity of intravitreal trovafloxacin in the pigmented rabbit. Cur. Eye Res., 2003, v. 27, № 6, p. 387-393.

[7]	Saitoh A., Taniguchi H., Gong H.et al. Long-term effect on optic nerve of silicone oil tamponade in rabbits: histological and EDXA findings. Eye, 2002, v. 16, № 2, p. 171-176.