EMBRYONIC SOURCES OF «RESERVE CELLS» DEVELOPMENT IN THE EPITHELIAL LINING OF THE CERVIX

Abstract

Using general histological and immunohistochemical methods, the sources of «reserve cells» of the epithelial lining of the uterus and vagina were studied on the material obtained from human embryos and fetuses. From 13th to 20th week of fetal development, the epithelial lining of the cervix was formed with the participation of the urogenital sinus (UGS). The cells of the latter interacted with the coelomic epithelial cells of the paramesonephric ducts (PMD). After 25th week, UGS cells were dispersed along the length of the cervix, lying on the basement membrane beneath the columnar epithelial cells. It is suggested that epitheliocytes of UGS are the source of the «reserve cells». Taking into account the tissue nature of the «reserve cell» it is expedient to determine them as mesonephroblasts. Cells are present in the cervical epithelium as a concomitant determined cellular differon.

Keywords

«reserve cells» / cervix / paramesonephric ducts / urogenital sinus

References

[1] Апгар Б., Броцман Г., Шпицер М. Клиническая кольпоскопия. М.: Практ. мед., 2012.

[2] Бродский В. Я. Трофика клетки. М.: Наука, 1966.

[3] Комплексная борьба с раком шейки матки: краткое практическое руководство. Женева: ВОЗ, 2008.

[4] Метаплазия тканей: материалы симпозиума по метаплазии тканей. М.: Наука, 1970.

[5] Молдавская А. А., Федорова Н. Н. Развитие производных парамезонефральных каналов. Астрахань: изд. Астраханск. гос. мед. акад., 2000.

[6] Нейштадт Э. Л., Крулевский В. А. Дифференциальная диагностика опухолей шейки матки. СПб.: КультИнформПресс, 2012.

[7] Роговская С. И. Папилломавирусная инфекция у женщин и патология шейки матки. М.: ГЭОТАР-Медиа, 2008.

[8] Титмушш Э., Адамс К. Шейка матки: цитологический атлас. М.: Практ. мед., 2009.

[9] Хлопин Н. Г. Общебиологические и экспериментальные основы гистологии. Л.: Изд-во АН СССР, 1946.

[10] Янин В. Л., Дунаев П. В., Соловьев Г. С. и др. Мезонефрос. Екатеринбург: Изд-во УрО РАН, 2000.

[11] Bulkmans N. W., Berkhof J., Rozendaal L. et al. Human papillomavirus DNA testing for the detection of cervical intraepithelial neoplasia grade 3 and cancer: 5-year followup of a randomised controlled implementation trial // Lancet. 2007. Vol. 370. № 9601. P. 1764-1772.

[12] Hashimoto R. Development of the human mullerian duct in the sexually undifferentiated stage // Anat. Rec. 2003. Vol. 272A, № 2. P. 514-519.

[13] Kurita T. Normal and abnormal epithelial differentiation in the female reproductive tract // Differentiation. 2011. Vol. 82, № 3. P. 117-126.

[14] Naucler P. W., Ryd S., Tőrnberg S. et al. Human papillomavirus and Papanicolaou tests to screen for cervical cancer // N. Engl. J. Med. 2007. Vol. 357, № 16. P. 1589-1597.

RIGHTS & PERMISSIONS

Eco-Vector