THE EFFECT OF PERINATAL HYPOXIA ON THE STRUCTURE OF BLOOD-BRAIN BARRIER IN RATS TREATED WITH SALIFEN
V. A. Otellin , L. I. Khozhai , I. N. Tyurenkov
Morphology ›› 2015, Vol. 148 ›› Issue (6) : 34 -37.
THE EFFECT OF PERINATAL HYPOXIA ON THE STRUCTURE OF BLOOD-BRAIN BARRIER IN RATS TREATED WITH SALIFEN
The work was performed on Wistar rats, which were divided into 3 groups: 1st group - experimental rats subjected to hypoxia and treated with salifen (15 mg/kg for 14 days), 2nd group - control rats exposed to hypoxia only without treatment, and 3rd group - intact animals (8-10 animals in each group). Using the methods of light and electron microscopy, the effect of salifen on the structural characteristics of the elements of the blood-brain barrier (BBB) in the neocortex was studied in rats after exposure to hypoxia in the early postnatal period - on postnatal Day 2 (model of human preterm pregnancy). The results showed that salifen had a positive effect on the state of the microvasculature after perinatal hypoxia, in particular, on the state of endothelial cells. Its active participation in the compensatory-adaptive reactions of the BBB in response to hypoxia exposure was detected, and the prospects of further studies of the protective properties of salifen are emphasized
perinatal hypoxia / neocortex / endothelial cells / blood-brain barrier / salifen
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