INTRANUCLEAR IRON DISTRIBUTION IN THE PURKINJE CELLS OF HUMAN CEREBELLUM

D. E. Korzhevskiy; Ye. G. Sukhorukova; V. V. Gusel’nikova; O. V. Kirik; I. P. Grigoriyev

doi:10.17816/morph.398909

Morphology ›› 2015, Vol. 148 ›› Issue (4) : 49 -51. DOI: 10.17816/morph.398909

Articles

brief-report

INTRANUCLEAR IRON DISTRIBUTION IN THE PURKINJE CELLS OF HUMAN CEREBELLUM

Author information +

History +

PDF

Abstract

The distribution of iron ions in the cerebellum of 15 human subjects aged 20-89-years was studied using highly-sensitive variant of Perls’ histochemical technique. Increased iron content was found in the white matter and in Purkinje cells. In 10 out of 15 cases examined iron was detected in the nuclei of Purkinje cells, while in some cases iron was found in the nucleolus.

Keywords

cerebellum / Purkinje cells / cell nucleus / nucleolus / iron

Cite this article

Download citation ▾

D. E. Korzhevskiy, Ye. G. Sukhorukova, V. V. Gusel’nikova, O. V. Kirik, I. P. Grigoriyev. INTRANUCLEAR IRON DISTRIBUTION IN THE PURKINJE CELLS OF HUMAN CEREBELLUM. Morphology, 2015, 148(4): 49-51 DOI:10.17816/morph.398909

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Сухорукова Е. Г., Григорьев И. П., Колос Е. А., Коржевский Д. Э. Ядрышко клетки - место накопления железа в нейронах черного вещества головного мозга человека // Морфология. 2012. Т. 142, вып. 6. С. 61-62.

[2]	Bower J. M., Parsons L. M. Rethinring the lesser brain // Sci. Amer. 2003. Vol. 289, № 2. P. 51-57.

[3]	Li Volti G., Ientile R., Abraham N. G. et al. Immunocytochemical localization and expression of heme oxygenase-1 in primary astroglial Cell. cultures during differentiation: effect of glutamate // Biochem. Biophys. Res. Commun. 2004. Vol. 315, № 2. P. 517- 524.

[4]	Meguro R., Asano Y., Odagiri S. et al. Nonheme-iron histo chemistry for light and electron microscopy: a historical, theoretical and technical review // Arch. Histol. Cytol. 2007. Vol. 70, № 1. P. 1-19.

[5]	Roschzttardtz H., Grillet L., Isaure M.-P. et al. Plant Cell nucleolus as a hot spot for iron // J. Biol. Chem. 2011. Vol. 286, № 32. P. 27863-27866.

[6]	Schmahmann J. D. Cerebrocerebellar system: anatomic substrates of the cerebellar contribution to cognition and emotion // Int. Rev. Psychiatry. 2001. Vol. 13, № 2. P. 247-260.

[7]	Schmahmann J. D., Caplan D. Cognition, emotion and cerebellum // Brain. 2006. Vol. 129, Pt. 2. P. 290-292.

[8]	Youdim M. B., Stephenson G., Ben Shachar D. Ironing iron out in Parkinson’s disease and other neurodegenerative diseases with iron chelators: a lesson from 6-hydroxydopamine and iron chelators, desferal and VK-28 // Ann. N. Y. Acad. Sci. 2004. Vol. 1012. P. 306-325.

[9]	Yung B. Y., Yang Y. H., Bor A. M. Nucleolar protein B23 translocation after deferoxamine treatment in a human leukemia Cell line // Int. J. Cancer. 1991. Vol. 48, № 5. P. 779-784.