MORPHOLOGICAL PECULIARITIES OF NEUROPEPTIDE Y-ERGIC INNERVATION OF THE HEART IN POSTNATAL ONTOGENESIS

Abstract

Neuropeptide Y (NPY)-containing fibers and intramural ganglionic neurons, as well as Y 1 and Y 2 receptors to NPY were detected in the myocardium of rats during postnatal ontogenesis using immunohistochemical methods. The data obtained suggest age-dependent changes of the NPY-mediated heart innervation. The density of NPY-positive fibers was the least in newborn animals and increased during first 20 days of life. Y 1 and Y 2 receptors were found in the heart of newborn and more adult rats. Y 1 receptors were observed in the coronary heart arteries, arterioles and cardiomyocytes from the moment of birth. The density of NPY Y 2 receptors was very low in the cardiac muscle of young (prior to the 2 nd month of age) and adult (up to 1 year-old) rats but substantially increased in aged animals. During the postnatal ontogenesis? all the intramural ganglionic neurons were Y 1-positive and Y 2-negative.

Keywords

heart / innervation / intramural ganglia / neuropeptide Y / receptors

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