LIVER, LUNG, KIDNEY AND SPLEEN MACROPHAGES IN RATS AFTER INTRAVENOUS ADMINISTRATION OF THE MODIFIED MAGNETITE NANOPARTICLES

I. V. Mil’to

doi:10.17816/morph.398785

Morphology ›› 2014, Vol. 146 ›› Issue (5) : 40 -45. DOI: 10.17816/morph.398785

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LIVER, LUNG, KIDNEY AND SPLEEN MACROPHAGES IN RATS AFTER INTRAVENOUS ADMINISTRATION OF THE MODIFIED MAGNETITE NANOPARTICLES

I. V. Mil’to

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Abstract

Using the immunohistochemical method, mononuclear phagocytes (MNPs) were detected in the liver, lung, kidneys and spleen of rats after a single intravenous injection of a suspension of magnetoliposomes and magnetic microspheres prepared on the basis of nanoscale magnetite particles of (NMPs). The dynamics of the of the number and topography of CD68 +- and CD163 +-cells in liver, lung and kidneys was characterized during 120 days after the intravenous injection of the suspension of modified NMPs. It was shown that NMPs surface modification reduced the degree and duration of macrophage activation. Signs of MNPs activation after the infusion of nanomaterial decreased in the following series: unmodified NMPs, magnetoliposomes, magnetic microspheres

Keywords

macrophages / CD68 - and CD163 cells / magnetite nanoparticles / magnetoliposomes

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I. V. Mil’to. LIVER, LUNG, KIDNEY AND SPLEEN MACROPHAGES IN RATS AFTER INTRAVENOUS ADMINISTRATION OF THE MODIFIED MAGNETITE NANOPARTICLES. Morphology, 2014, 146(5): 40-45 DOI:10.17816/morph.398785

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