NeuN NUCLEAR PROTEIN IN NEURONS OF HUMAN BRAIN SUBSTANTIA NIGRA

Abstract

The expression of NeuN protein was examined immunocytochemically in the neurons of human substantia nigra (n=14, age: 27–78 years). Some of substantia nigra neurons demonstrated weak NeuN immunopositive reaction, while the others were NeuN-immunonegative. In general, NeuN immunocytochemical reaction in neurons of human substantia nigra was expressed much weaker than in the nucleus rubrum neurons located in the same sections.

Keywords

brain / substantia nigra / NeuN nuclear protein / man

References

[1] Григорьев И. П., Сухорукова Е. Г., Колос Е. А. и Коржевский Д. Э. Нейромеланин в нейронах черного вещества, не содержащих тирозингидроксилазу. Морфология, 2012, т. 141, вып. 2, с. 65–67.

[2] Коржевский Д. Э., Петрова Е. С., Кирик О. В. и др. Нейральные маркеры, используемые при изучении дифференцировки стволовых клеток. Клеточная трансплантология и тканевая инженерия, 2010, т. 5, №. 3, с. 57–63.

[3] Отеллин В. А. и Арушанян Э. Б. Нигрострионигральная система. М., Медицина, 1989.

[4] Cannon J. R. and Greenamyre J. T. NeuN is not a reliable marker of dopamine neurons in rat substantia nigra. Neurosci. Lett., 2009, v. 464, № 1, p. 14–17.

[5] Kumar S. S. and Buckmaster P. S. Neuron-specific nuclear antigen NeuN is not detectable in gerbil subtantia nigra pars reticulate. Brain Res., 2007, v. 1142, p. 54–60.

[6] Mullen R. J., Buck C. R. and Smith A. M. NeuN, a neuronal specific nuclear protein in vertebrates. Development, 1992, v. 116, № 1, p. 201–11.

RIGHTS & PERMISSIONS

Eco-Vector