PECULIARITIES OF ANGIOGENESIS AFTER THE IMPLANTATION OF POLYHYDROXYALKANOATE FILMS WITH THE ADSORBED MULTIPOTENT STROMAL STEM CELLS OF A BONE MARROW ORIGIN

I. V. Maiborodin; A. I. Shevela; V. V. Morozov; Ya. V. Novikova; V. A. Matveyeva; M. N. Drovosekov; M. I. Barannik; S. V. Marchukov; I. V. Kuznetsova

doi:10.17816/morph.398618

Morphology ›› 2013, Vol. 143 ›› Issue (1) : 041 -047. DOI: 10.17816/morph.398618

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PECULIARITIES OF ANGIOGENESIS AFTER THE IMPLANTATION OF POLYHYDROXYALKANOATE FILMS WITH THE ADSORBED MULTIPOTENT STROMAL STEM CELLS OF A BONE MARROW ORIGIN

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Abstract

The processes developing in various rat tissues after implantation of polymeric polyhydroxyalkanoate (PHA) film fragments with adsorbed autologous multipotent stromal (mesenchymal) cells of bone marrow origin (AMMSCBM), were studied by methods of light microscopy. After the implantation of PHA film with AMMSCBM, the number of blood vessels in the surrounding tissues was found to increase as a result of neoangiogenesis. In this case, AMMSCBM did not migrate and were not destroyed at the place of injection, but differentiated into the cells forming blood vessel structures. The processes of angiogenesis in the tissues around PHA implant, in turn, lead to development of a larger number of blood vessels in the granulations formed around the implanted foreign body, higher volume of granulations proper and subsequent development of a thicker capsule delimiting polymer implant.

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multipotent stromal (mesenchymal) cells / polyhydroxyalkanoate / implantation / angiogenesis / granulomatous inflammation

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I. V. Maiborodin, A. I. Shevela, V. V. Morozov, Ya. V. Novikova, V. A. Matveyeva, M. N. Drovosekov, M. I. Barannik, S. V. Marchukov, I. V. Kuznetsova. PECULIARITIES OF ANGIOGENESIS AFTER THE IMPLANTATION OF POLYHYDROXYALKANOATE FILMS WITH THE ADSORBED MULTIPOTENT STROMAL STEM CELLS OF A BONE MARROW ORIGIN. Morphology, 2013, 143(1): 041-047 DOI:10.17816/morph.398618

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