IMMUNE REACTIVITY OF HUMAN LENS STRUCTURES IN NORM, AGE-RELATED CORTICAL AND SECONDARY OPACIFICATION

N. V. Korsakova; Ye. M. Luzikova; O. A. Shatskykh; A. V. Nikiforova; N. I. Larionova

doi:10.17816/morph.398607

Morphology ›› 2013, Vol. 143 ›› Issue (1) : 028 -031. DOI: 10.17816/morph.398607

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IMMUNE REACTIVITY OF HUMAN LENS STRUCTURES IN NORM, AGE-RELATED CORTICAL AND SECONDARY OPACIFICATION

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Abstract

Using immunohistochemical methods, the immune reactivity of human lens epithelium and fibers to NSE, S-100 protein, Vim, α-SMA and EMA was studied in 10 normal persons and in 25 patients with its age-related cortical and secondary cataract. It was demonstrated that in age-related cortical and secondary cataract lens epithelium and fibers became more reactive to antibodies against NSE, S-100 protein and Vim, but showed no immunopositivity to α-SMA and EMA. Thus, the data obtained suggest some common pathogenetic mechanisms of age-related cortical and secondary cataract development with the formation of Adamyuk–Elschnig pearls.

Keywords

lens / secondary cataract / age-related cataract / cell phenotype / pathogenesis

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N. V. Korsakova, Ye. M. Luzikova, O. A. Shatskykh, A. V. Nikiforova, N. I. Larionova. IMMUNE REACTIVITY OF HUMAN LENS STRUCTURES IN NORM, AGE-RELATED CORTICAL AND SECONDARY OPACIFICATION. Morphology, 2013, 143(1): 028-031 DOI:10.17816/morph.398607

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