IMMUNE REACTIVITY OF HUMAN LENS STRUCTURES IN NORM, AGE-RELATED CORTICAL AND SECONDARY OPACIFICATION
N. V. Korsakova , Ye. M. Luzikova , O. A. Shatskykh , A. V. Nikiforova , N. I. Larionova
Morphology ›› 2013, Vol. 143 ›› Issue (1) : 028 -031.
IMMUNE REACTIVITY OF HUMAN LENS STRUCTURES IN NORM, AGE-RELATED CORTICAL AND SECONDARY OPACIFICATION
Using immunohistochemical methods, the immune reactivity of human lens epithelium and fibers to NSE, S-100 protein, Vim, α-SMA and EMA was studied in 10 normal persons and in 25 patients with its age-related cortical and secondary cataract. It was demonstrated that in age-related cortical and secondary cataract lens epithelium and fibers became more reactive to antibodies against NSE, S-100 protein and Vim, but showed no immunopositivity to α-SMA and EMA. Thus, the data obtained suggest some common pathogenetic mechanisms of age-related cortical and secondary cataract development with the formation of Adamyuk–Elschnig pearls.
lens / secondary cataract / age-related cataract / cell phenotype / pathogenesis
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