PECULIARITIES OF AGE CHANGES OF NF200+-NEURONS IN THE SENSORY GANGLIA OF DIFFERENT SEGMENTAL LEVELS AFTER CHEMICAL DEAFFERENTATION
Valentina Vyacheslavovna Porseva , Valentin Viktorovich Shilkin , Marina Borisovna Korzina , Viktoriya Pavlovna Smirnova , Petr Mikhaylovich Maslyukov , V V Porseva , V V Shilkin , M B Korzina , V P Smirnova , P M Maslyukov
Morphology ›› 2012, Vol. 142 ›› Issue (4) : 37 -42.
PECULIARITIES OF AGE CHANGES OF NF200+-NEURONS IN THE SENSORY GANGLIA OF DIFFERENT SEGMENTAL LEVELS AFTER CHEMICAL DEAFFERENTATION
Morphological features of the neurons containing neurofilaments with molecular mass of 200 kD (NF200+), were studied in the sensory ganglia of thoracic and lumbar spinal nerves in rats (n=80) during the first year of their life. Capsaicin treatment (150 mg/kg) of the newborn animals resulted in the change of age dynamics of NF200+ neurons. This was reflected by a reduction of NF200+ neuron numbers and their cross-sectional areas in both ganglia. Segmental differences included greater reduction of NF200+ neuron number in the sensory ganglion of lumbar spinal nerve in both early and late developmental periods.
neuron / sensory ganglion of thoracic spinal nerve / sensory ganglion of lumbar spinal nerve / 200 kD neurofilaments / capsaicin
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