ONTOGENESIS OF THE BRAIN HISTAMINERGIC NEURAL SYSTEM
S. M. Zimatkin , R. M. Fedina , A. V. Zayerko
Morphology ›› 2018, Vol. 154 ›› Issue (5) : 70 -77.
ONTOGENESIS OF THE BRAIN HISTAMINERGIC NEURAL SYSTEM
The purpose of this review is to analyze the literature data on the development of histaminergic system of the brain in ontogenesis of animals and humans. On Days 13-17 of rat embryogenesis, a temporary transitional histaminergic system exists in the midbrain, pons and medulla, in which the histamine is colocalized in neurons with the serotonin. The first histaminergic neurons in the posterior hypothalamus by Day 16 of embryogenesis. By the time of birth, they form there 5 clusters of nuclei (E1- E5), characteristic for the adult vertebrates and reaching definitive characteristics by postnatal Day 20. The development of the histaminergic system in rats has a specific character, while in the ontogenesis of fish Danio rerio and tat one of humans, a transitional histaminergic system is not detected.
brain / histaminergic neurons / development
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