STRUCTURAL CHANGES OF SKELETAL MUSCLE IN LOCAL HYPERTENSIVE ISCHEMIC SYNDROME

Abstract

Objective - to study the peculiarities of structural changes of skeletal muscle in animal model of local hypertensive ischemic syndrome. Material and methods. Histological examination of thigh muscles from adult rabbits of both sexes was performed in normal animals and at various time intervals after application of a pneumatic tourniquet on the femoral upper third for 4 hrs under 80-100 mm Hg pressure (3 control and 14 experimental animals). Results. A pneumatic tourniquet with an exposure of 4 hrs caused thigh muscle edema, muscle fiber structural homogenization and contraction. Starting on day 7 after removal of the pneumatic tourniquet, the ischemic muscles were characterized by a progressive proliferation of connective tissue cells with the development of fibrous tissue and the intensification of degenerative changes in muscle fibers. Conclusions. Exposure of skeletal muscle of rabbit thigh to a local hypertensive ischemia for 4 hrs under 80-100 mm Hg pressure resulted in the development of scar-fibrotic degeneration of soft tissues, characteristic for ischemic syndrome.

Keywords

skeletal muscle / muscle fibers / post-ischemic tissue changes

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