CHARACTERIZATION OF CART PEPTIDEIMMUNOPOSITIVE CELLS OF THE SUBVENTRICULAR ZONE OF THE BRAIN

Abstract

Objective - to study cytoarchitectonics, neuronal organization and the distribution of CART peptide-immunopositive cells in the subventricular zone of the brain. Material and methods. The study was performed on the frontal sections of the rat brain (n=18) using Nissle, Golgi methods and immunohistochemistry with antibodies against CART (55- 102). The preparations were analyzed using light microscopy. Results. CART peptide-immunopositive cells were detected in the subventricular zone of the lower horn of the lateral ventricle within the paleoamygdala. They have round-to-oval cell bodies, one or two short processes and, according to their neural organization, are neuroblastomorph neurons. Conclusions. The data obtained indicate that cells of the subentricular zone express CART peptide under normal conditions. This predetermines high efficiency of neuroregenerative therapy conducted with its use.

Keywords

paleoamygdala / corpus amygdaloideum of the brain / CART peptide / neuroregeneration / ischemic stroke

References

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