STRUCTURAL CHARACTERISTICS OF THE MONOCHORIONIC PLACENTA IN MONOZYGOTIC TWINS

Abstract

Histological, histochemical, immunohistochemical and morphometric methods were used to study 12 samples of placenta with the mass of 650-800 g, obtained from monozygotic twins with common chorion, and 12 samples of placenta with the mass of 450-550 g from singleton pregnancies. Gestational age was 39-40 weeks, the course of pregnancy was without pathology and resulted in uncomplicated delivery. In the epithelium of the terminal villi in the placenta of the monozygotic twins, the number of Ki-67-immunopositive nuclei was 3 times higher than in placentas in singleton pregnancies. The number of Ki-67-immunopositive nuclei in the endothelium and in smooth muscle cells of the blood vessels in the villi in twin pregnancy was higher that in singleton pregnancy. These data indicate that the mechanisms of angiogenesis is involved in the vascularization of the villi. The results obtained in this study suggest that the villous tree in the monochorionic placenta in the development of twins in humans was characterized by incomplete histogenesis of the main structural components of the terminal villi.

Keywords

Ki-67 / monozygotic twins / monochorionic placenta / terminal villi / proliferation / Ki-67

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