GENDER-RELATED PECULIARITIES OF THE MYOCARDIAL REGENERATIVE CAPACITIES IN EXPERIMENTAL CARDIAC FAILURE

Abstract

Myocardium of the left ventricle was studied in rats (n=40) of both sexes with an experimental heart failure (HF) using light microscopy, immunocytochemistry and morphometry. The substantial reorganization of the muscular and stromal elements of the myocardium was found in animals with HF. Both remodeling and regenerative capacities of the myocardium in animals with HF demonstrated gender-associated peculiarities. Gender-related distinctions were also found in the expression of Ki-67, caspase 9 and vimentin. The role of the cardioprotective effects of estrogens on the myocardium of the left ventricle as well as the importance of other factors influencing gender-related characteristics of myocardium regeneration in HF, are discussed.

Keywords

cardiomyocytes / regeneration / remodeling / heart failure / gender

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