DISTRIBUTION OF LIPOFUSCIN IN HUMAN CEREBELLAR CORTEX
Ye. G. Sukhorukova , Ye. G. Gilerovich , M. A. Syrtsova , A. D. Novikova , D. E. Korzhevskiy
Morphology ›› 2016, Vol. 150 ›› Issue (6) : 25 -28.
DISTRIBUTION OF LIPOFUSCIN IN HUMAN CEREBELLAR CORTEX
Lipofuscin is a recognized intracellular marker of aging. The purpose of this study was to establish the topographic pattern of distribution of lipofuscin granule clusters in the cerebellar cortex. With the use of fluorescence microscopy The pigment was demonstrated due to its property of autofluorescence, in the sections of human cerebellar cortex (n=25, age 20-89 years). The analysis of preparations showed the presence of lipofuscin granules, predominantly with yellow-green autofluorescence, in different layers of the cerebellar cortex. A tendency of these granules to increase in number and sizes with age was detected. Lipofuscin was found to accumulate in the layers of cerebellar cortex unevenly. Most pronounced lipofuscin clusters were seen in the Purkinje cells, where a shift of its intracellular localization from perinuclear to the site of the processes’ origin was observed.
cerebellar cortex / lipofuscin / man / fluorescence microscopy
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