LOCALIZATION OF ALPHA-SYNUCLEIN IN RAT BRAIN AND ITS INTERRELATION WITH THE DOPAMINERGIC STRUCTURES

Abstract

Localization of alpha-synuclein (α-Syn - the protein found in Lewy bodies in Parkinson’s desease) and tyrosine hydroxylase (a marker of dopamin- and noradrenergic neurons) were studied by immunohistochemical methods in brain structures of intact Wistar rats (n = 5) and compared with the data obtained after destruction of substantia nigra (n = 3). Localization of α-Syn in synaptic structures of basal ganglia corresponded to cortico-striatal and strio-nigral projections, which was confirmed experimentally. In the cell bodies of dopamin- and noradrenergic neurons, α-Syn was found in the substantia nigra, locus coeruleus and in the dorsal nucleus of nervus vagus, prone to neurodegeneration in in Parkinson’s desease. High α-Syn content was also found in sensory olfactory neurons and glomeruli of the olfactory bulbs.

Keywords

brain / basal ganglia / dopaminergic systems / alpha-synuclein / tyrosine hydroxylase

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