CHANGES OF PANCREATIC ISLET A CELLS AFTER PHYSICAL LOADS IN GLUCOSE TOLERANCE IMPAIREMENT

Abstract

The aim of the work was to study the structural changes of A pancreatic islet cells of the in dogs with impaired glucose tolerance after a single moderate or regular physical activity. The experiments were performed on 28 adult male dogs aged 2-4 years, 10 of them served as the control group. Pancreatic islet A cell structure was examined using histological, electron microscopic and morphometric methods. Results of the study to demonstrated variations in the localization of A cells in the pancreatic islets of dogs depending on the state of body carbohydrate metabolism. More pronounced structural changes developed in A cells after a training cycle. Along with the compensatory-adaptive response, the cells developed changes indicating their functional stress (reduction of the relative volume of cells and of secretory granules, «empty spaces» in the cytoplasm, hypertrophied Golgi complex) and the depletion of energy reserves (rarification of mitochondrial matrix and cristae destruction).

Keywords

pancreas / A-cells / impaired glucose tolerance / physical loads

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