REPARATIVE OSTEOGENESIS IN TREATMENT OF A CAVITARY BONE DEFECT UNDER CONDITIONS OF IMPLANTATION OF THREE-DIMENSIONAL TITANIUM NICKELIDE MESH CONSTRUCTIONS

Abstract

Reparative osteogenesis and tissue integration characteristics were studied after the implantation of three-dimensional titanium nickelide mesh constructions into a cavitary bone defect. Cavitary defects of femoral metaphysis were modeled in 2 groups of Wistar rats: experimental group (n=20) and control group (n=20). The intact metaphysis of contrlateral extremity was also studied. Total experiment duration was 60 days. Radiography, light and electron microscopy, X-ray electron probe microanalysis were used. After the implantation, cancellous bone filled the defect; the volumetric density of this bone exceeded the control values more than 1.5 times. The implant was biocompatible, it had osteoconductive and osteoinductive properties and suppressed inflammatory processes. In the defect periosteal zone a protective barrier was formed on the implant surface which prevented connective tissue sprouting. Reparative osteogenesis followed direct intramembranous and apposition pattern. It was found that implants of three-dimensional mesh titanium-nickelide constructions had marked osteoplastic properties and could be successfully used in orthopedic surgery.

Keywords

bone defect / reparative osteogenesis / implant / three-dimensional mesh structures / titanium nickelide

References

[1] Ирьянов Ю. М., Ирьянова Т. Ю. Замещение дефекта кости в условиях чрескостного остеосинтеза и применения имплантата из никелида титана // Морфология. 2012. Т. 142, вып. 4. С. 83-86.

[2] Корж Н. А., Кладченко Л. А., Малышкина С. В. Имплантационные материалы и остеогенез. Роль оптимизации и стимуляции в реконструкции кости // Ортопед., травматол. и протезирование. 2008. № 4. С. 5-14.

[3] Миронов С. П.,Кокорина Е. П.,Андреева Т. М.,Огрызко Е. В. Состояние травматолого-ортопедической помощи населению Российской Федерации // Вестн. травматол. и ортопед. им. Н. Н. Приорова. 2007. № 3. С. 3-10.

[4] Патент РФ № 111759. Имплантат для замещения дефекта кости / Ю. М. Ирьянов, Т. Ю. Ирьянова. Заявка от 27.06.2011 г. // Опубл. в БИ. 2011. № 36. С. 1-2.

[5] Чернов В. Ф., Бевзюк А. Н., Чернов А. В., Ирьянов Ю. М. Изучение имплантации сетчатых конструкций из никелида титана // Мед. наука образ. Урала. 2008. № 2. С. 98-100.

[6] Dahlin C., Linde A., Gottlow J., Nyman S. Healing of bone defects by guided tissue regeneration // Plast. Reconstr. Surg. 2008, Vol. 81. P. 672-676.

[7] Gottlow J., Nyman S., Lindhe J. et al. New attachment formation in the human periodontium by guided tissue regeneration. Case reports // J. Clin. Periodontol. 1986. Vol. 13. P. 604-616.

[8] Iriyanov Yu.M., Chernov V.F., Radchenko S. A., Chernov A. V. Plastic efficiency of different implants used for repair of soft and bone tissue defects // Bull. Exp. Biol. Med. 2013. Vol. 155, № 4. P. 518-521.

[9] Irianov Y. M., Diuriagina O. V., Karaseva T. Y. The osteoplastic effectiveness of the implants made of mesh titanium nickelide constructs // Bosn. J. Basic Med. Sci. 2014. Vol. 14, № 1. P. 4-7.

[10] Nyman S., Gottlow J., Lindhe J. et al. New attachment formation by guided tissue regeneration // J. Periodontal. Res. 1987. Vol. 22. P. 252-254.

[11] Ripamonti U., Herbst N., Ramoshebi N. Bone morphogenetic proteins in craniofacial and periodontal tissue engineering: experimental studies in the non-human primate Papio ursinus // Cytokine Growth Factor Rev. 2005. Vol. 16. P. 357-368.

[12] Uebersax L., Hagenmüller H., Hofmann S. et al. Effect of scaffold design on bone morphology in vitro // Tissue Eng. 2006. Vol. 12. P. 3417-3429.

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