HISTOLOGICAL CHANGES IN THE KNEE JOINT SYNOVIAL FLUID IN EXPERIMENTAL MODELING OF OSTEOARTHROSIS AND ORTHOPEDICBONE LENGTHENING IN DOGS

Abstract

The experiment was aimed at studying the structural reorganization of the knee joint synovium in dogs with modeling of primary osteoarthrosis (MOP) and tibial lengthening (TL). The methods of light microscopy and histomorphometry of semithin epoxy sections were used to assess the thickness of synovial surface layer, number of synoviocyte layers, characterize the cells, to measure the numerical density of vessels, and to define the changes of the nerves and cell composition of the subsynovial layer. In MOP-group, the predominance of type А synoviocytes, hypovascularity and irreversible changes in the nerves of subsynovial sheath were observed. In TL-group, the diversity of type В synoviocyte forms and sizes, hypervascularity of subsynovial layer and signs of its re-innervation were detected. It is concluded that the hyperplastic synoviopathy is possible in cases of both hypo- and hypervascularization of subsinovial layer.

Keywords

synovium / osteoarthrosis modeling / tibial lengthening

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