INFLUENCE OF CHITOSANMODIFIED MAGNETIC NANOSPHERES ON ERYTHROPOIESIS OF RATS

I. V. Mil’to; N. M. Shevtsova; V. V. Ivanova; I. O. Gabitova; L. A. Safiullina; I. V. Sukhodolo

doi:10.17816/morph.101902

Morphology ›› 2019, Vol. 156 ›› Issue (4) : 99 -101. DOI: 10.17816/morph.101902

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INFLUENCE OF CHITOSANMODIFIED MAGNETIC NANOSPHERES ON ERYTHROPOIESIS OF RATS

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Abstract

Objective - to study the effect of single intravenous injection of suspension of chitosan-modified magnetic nanospheres on rat erythropoiesis. Material and methods. Smears of rat bone marrow were examined at 1, 7, 14, 21, 40, 60, 90, and 120 days after intravenous injection of magnetic nanospheres. Results. Injection of chitosan-modified magnetic nanospheres suspension provoke no change the morphology of the blood cells, and cause reversible decrease in erythroid maturation ratio and an increase in myelo-erythroid ratio. Conclusions. Injection of chitosan-modified magnetic nanospheres suspension cause reversible changes in rat erythropoiesis.

Keywords

red bone marrow / erythropoiesis / nanomagnetite particles / magnetic nanospheres / chitosan

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I. V. Mil’to, N. M. Shevtsova, V. V. Ivanova, I. O. Gabitova, L. A. Safiullina, I. V. Sukhodolo. INFLUENCE OF CHITOSANMODIFIED MAGNETIC NANOSPHERES ON ERYTHROPOIESIS OF RATS. Morphology, 2019, 156(4): 99-101 DOI:10.17816/morph.101902

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